PMID: 7546986Aug 1, 1995Paper

Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation

British Heart Journal
L C AdèsJ F Bateman

Abstract

Ehlers-Danlos syndrome encompasses a group of inherited disorders of connective tissue, some of which are characterised by abnormalities of collagen metabolism. The chromosomal location, identified genes and biochemical defects, inheritance pattern, and clinical features for the various known subtypes are outlined. Prenatal diagnosis is possible for types IV, VI, VIIA1, and VIIA2. An unusual presentation of type IV Ehlers-Danlos syndrome in a 16 year old boy with an anterior myocardial infarction resulting from dissection of the left anterior descending coronary artery is reported here. A clinical diagnosis of type IV Ehlers-Danlos syndrome was made subsequently and confirmed by the reduced production, impaired secretion, and abnormally slow electrophoretic migration of type III collagen, indicating an underlying mutation in the COL3A1 gene. This patient represents the first case of type IV Ehlers-Danlos syndrome with symptomatic coronary artery dissection.

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Citations

Dec 5, 2003·The American Journal of Emergency Medicine·Ayoub Mirza
Jun 3, 2008·Cardiovascular Ultrasound·Jayanth R ArnoldAdrian P Banning
Jul 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayuki NakagawaKen-ichi Hirata
Dec 1, 2010·AJR. American Journal of Roentgenology·Sivan LiebermanElina Yamada
Oct 30, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W TanisF H de Man
Mar 17, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexandre C Zago, Bruno S Matte
Apr 29, 2006·Journal of Cardiovascular Medicine·Corrado Vassanelli
Nov 3, 2016·Journal of Community Hospital Internal Medicine Perspectives·Yenal HarperShadwan Alsafwah
Sep 8, 2000·The Australian and New Zealand Journal of Surgery·C N FahrerE A Shanahan
Dec 21, 2017·The New England Journal of Medicine·Sarah V TsiarasMalissa J Wood
Feb 24, 2018·Circulation·Sharonne N HayesUNKNOWN American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular
Apr 9, 2019·Expert Review of Cardiovascular Therapy·Thomas S Gilhofer, Jacqueline Saw
Nov 26, 1998·Catheterization and Cardiovascular Diagnosis·P R Vale, D W Baron
Sep 20, 2006·The Journal of Trauma·Joseph T GarvinRonan Waldron

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