PMID: 9420777Mar 1, 1995Paper

Myocardial iodine-labeled metaiodobenzylguanidine 123 uptake relates to age

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Montserrat EstorchG Torres

Abstract

123I-labeled metaiodobenzylguanidine (123I-MIBG) is used increasingly to assess cardiac adrenergic neuron function. Few studies have reported data on myocardial MIBG uptake in relation to age, with contradictory results. This study reports the results of myocardial MIBG studies in untreated patients with cancer to assess the influence of age on myocardial MIBG uptake. Thirty-nine patients with cancer enrolled in a study to assess the effect of doxorubicin administration on adrenergic neuron function underwent baseline studies with 123I-MIBG before chemotherapy. None of the patients had a history of neuropathy, previous cardiac disease, or previous chemotherapy or mediastinal radiotherapy. Myocardial MIBG uptake was quantified by a heart/mediastinal ratio (HMR) 4 hours after intravenous administration of 5 mCi 123I-MIBG. The mean age of patients was 38 years, ranging from 16 to 75 years. Ten patients were below 20 years, 13 patients were between 20 and 40 years, six patients were between 40 and 60 years, and 10 patients were greater than 60 years of age. Myocardial 123I-MIBG uptake was observed in all patients, with a mean HMR of 1.85 +/- 0.29 (range 1.31 to 2.62). HMR correlated with age (r = -0.6264; p < 0.001). A decrease in ...Continue Reading

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Citations

Jun 29, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Montserrat EstorchJagat Narula
Feb 3, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Shohei Yamashina, Jun-ichi Yamazaki
Apr 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Shohei Yamashina, Jun-ichi Yamazaki
May 30, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Montserrat EstorchIgnasi Carrio
Jul 24, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Ignasi Carrió, Albert Flotats
Mar 14, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arnold F JacobsonErnest V Garcia
Mar 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G Aernout SomsenAlberto Righetti
Oct 9, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert Flotats, Ignasi Carrió
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wengen ChenHongming Zhuang
Mar 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·M W Dae
Jan 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·J LekakisS Moulopoulos
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