PMID: 8594926Dec 1, 1995Paper

Myocardial ischemia and reperfusion: a murine model

The American Journal of Physiology
L H MichaelC M Ballantyne

Abstract

Myocardial ischemia followed by reperfusion promotes a complex series of inflammatory reactions as noted in a variety of large animal studies. With development of genetically altered mice, there is intense interest in developing murine models to study mechanisms operative in cardiovascular disease. We developed a mouse model to study coronary artery occlusion and reperfusion effects and the method required to perform these studies both acutely and chronically. In mice, we applied a left anterior descending coronary artery occlusion either permanently or for 30 or 60 min followed by reperfusion allowing flow through the previously occluded coronary artery bed. Reperfusion was documented visually as well as by using Doppler ultrasound and histopathological techniques. The area at risk (AAR) and infarct size (IS) were assessed by EVans blue dye and triphenyltetrazolium chloride staining with computerized planimetry using an image analysis software program. The infarct as percentage of AAR and IS as percentage of the left ventricle in 13 mice with permanent occlusion was 68.6 +/- 4.4 and 28.0 +/- 2.8%, respectively. Reperfusion after occlusions of 60 and 30 min resulted in a significant decrease in IS as a percentage of the AAR com...Continue Reading

Citations

Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T O NossuliM L Entman
Mar 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·John E CaswellDavid J Lefer
Aug 30, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyFrancis G Spinale
May 16, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Antonio CurcioHoward A Rockman
Apr 5, 2011·Journal of Biomedical Optics·Markus HolottaWerner Jaschke
Jun 21, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jiqiu ChenRoger J Hajjar
Feb 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Barbara A MillerJoseph Y Cheung
Nov 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Adrian ChrastinaJan E Schnitzer
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K SuehiroS Homma
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S A BriaudC M Ballantyne
Oct 4, 2000·Physiological Genomics·D LynN L Emmett
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kenneth E GouldMark L Entman
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F SamW S Colucci
Jan 30, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yinhong ChenPaul F McDonagh
Aug 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zheqing P CaiLewis C Becker
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Tomohiro NishiokaKyoko Imanaka-Yoshida
Oct 21, 2010·NMR in Biomedicine·Bram F CoolenGustav J Strijkers
Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jean-François JasminMichael P Lisanti
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Linghua KongShi-Fang Yan
Jan 1, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jiqiu ChenRoger J Hajjar
Aug 11, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Xi-Ren GaoHai-Jie Wang
Dec 25, 2013·BioMed Research International·Tyler SpataAhmet Kilic
Mar 20, 2019·Basic Research in Cardiology·Lucas BacmeisterDiana Lindner
Sep 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anis HannaNikolaos G Frangogiannis
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T O NossuliM L Entman
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Tobias EckleHolger K Eltzschig
Feb 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Dongchoon AhnMark I Talan
Jul 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Koji SakaiKenji Sunagawa
Jul 10, 2002·ILAR Journal·Craig J HartleyLloyd H Michael
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hiromitsu KanamoriShinya Minatoguchi
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyGerd Heusch
Aug 28, 2020·Biomolecules·Olga M RusieckaBrenda R Kwak
Aug 7, 2001·Journal of Cardiovascular Pharmacology·J D OvercastS W May
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·W G GirodD J Lefer
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chunlian ZhangCam Patterson
Sep 14, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Kengo IsegawaKenji Sunagawa
May 3, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ewout J van den BosDirk J Duncker
May 29, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Andrea ProttiAjay M Shah
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Yasuko NagasakaKenneth D Bloch
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Venkatesh ManiZahi A Fayad
Mar 24, 2004·Journal of Pharmacological Sciences·Zhong-Fang LaiKatsuhide Nishi
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Fei TianLevent M Akyürek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.