PMID: 2488090Jan 1, 1989Paper

Myocardial ischemia and reperfusion: the role of oxygen radicals in tissue injury

Cardiovascular Drugs and Therapy
S W Werns, B R Lucchesi

Abstract

Thrombolytic therapy has gained widespread acceptance as a means of treating coronary artery thrombosis in patients with acute myocardial infarction. Although experimental data have demonstrated that timely reperfusion limits the extent of infarction caused by regional ischemia, there is growing evidence that reperfusion is associated with an inflammatory response to ischemia that exacerbates the tissue injury. Ischemic myocardium releases archidonate and complement-derived chemotactic factors, e.g., leukotriene B4 and C5a, which attract and activate neutrophils. Reperfusion of ischemic myocardium accelerates the influx of neutrophils, which release reactive oxygen products, such as superoxide anion and hydrogen peroxide, resulting in the formation of a hydroxyl radical and hypochlorous acid. The latter two species may damage viable endothelial cells and myocytes via the peroxidation of lipids and oxidation of protein sulfhydryl groups, leading to perturbations of membrane permeability and enzyme function. Neutrophil depletion by antiserum and inhibition of neutrophil function by drugs, e.g., ibuprofen, prostaglandins (prostacyclin and PGE1), or a monoclonal antibody, to the adherence-promoting glycoprotein Mo-1 receptor, have ...Continue Reading

References

Jul 1, 1978·Journal of Molecular and Cellular Cardiology·D J HearseG R Bullock
Apr 1, 1988·Mayo Clinic Proceedings·P A Southorn, G Powis
Jan 17, 1985·The New England Journal of Medicine·J M McCord
May 29, 1986·Biochemical and Biophysical Research Communications·D A PetersonJ M Gerrard
Mar 9, 1987·FEBS Letters·P C MoorhouseJ M Gutteridge
Oct 1, 1987·Journal of Clinical Pharmacology·E J Topol
Apr 1, 1988·Mayo Clinic Proceedings·P A Southorn, G Powis
Aug 1, 1988·The American Journal of Physiology·W R MostowA M Samarel
Dec 30, 1986·Biochemical and Biophysical Research Communications·C M GrumM Shlafer
Nov 1, 1987·Journal of Molecular and Cellular Cardiology·J M DowneyD M Yellon
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·B R Lucchesi, K M Mullane
Nov 1, 1986·The Journal of Clinical Investigation·R H SimonR F Todd
Feb 1, 1985·Journal of Molecular and Cellular Cardiology·D E ChambersJ M Downey
Jan 1, 1985·Molecular Aspects of Medicine·B Halliwell, J M Gutteridge
Jan 1, 1986·The Journal of Clinical Investigation·N S AgarJ W Eaton
Sep 1, 1969·The Journal of Experimental Medicine·J H Hill, P A Ward
Apr 1, 1971·The Journal of Experimental Medicine·J H Hill, P A Ward
Nov 1, 1984·The Journal of Clinical Investigation·M BergerM M Frank
Sep 1, 1982·The Journal of Clinical Investigation·S J WeissM Wei
Jun 15, 1984·European Journal of Pharmacology·M J SheaB R Lucchesi

❮ Previous
Next ❯

Citations

Apr 1, 1994·Molecular and Cellular Biochemistry·M D Osbakken
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z Sroka, W Cisowski
Oct 2, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G LippiG Guidi
Mar 18, 2004·Antioxidants & Redox Signaling·Hajime Otani
Jul 7, 2012·PloS One·Rong XiaoYue-sheng Huang
Jan 1, 1990·Radiation and Environmental Biophysics·M Saran, W Bors
Jul 7, 2007·Canadian Journal of Physiology and Pharmacology·Dinender K SinglaPawan K Singal
May 22, 1990·The American Journal of Cardiology·B R Lucchesi
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masashi TanakaRobert C Robbins
Jun 29, 1995·Biochemical Pharmacology·D LapennaF Cuccurullo
Dec 10, 2013·Bioorganic & Medicinal Chemistry·Steven A KatesReinier Beeuwkes
Aug 21, 2010·Journal of Pharmacological Sciences·Kaiwei SiXiaoqi Li
May 23, 2013·Circulation. Cardiovascular Imaging·Brian G Kral, Dara L Kraitchman
Feb 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Arun K ThukkaniDavid A Ford
Aug 7, 2001·Journal of Cardiovascular Pharmacology·W S WaringS R Maxwell
Sep 1, 1990·Circulation·R Bolli
Nov 6, 2020·Journal of Medical Virology·Xiucui Han, Qing Ye
Sep 21, 2000·The American Journal of Medicine·D J Lefer, D N Granger
Jan 1, 1996·Annales Françaises D'anesthèsie Et De Rèanimation·D LugrinD Grimaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.