PMID: 9420761Jan 1, 1995Paper

Myocardial lipid turnover in dilated cardiomyopathy: a dual in vivo tracer approach

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
L E FeinendegenB Strauer

Abstract

Myocardial lipid metabolism appears abnormal in dilated cardiomyopathy (DCM). A dual-tracer approach with two different fatty acid analogs may allow us to observe such alteration in vivo. 15-(Ortho-123I-phenyl)-pentadecanoic acid (oPPA) and 15-(para-123I-phenyl)-pentadecanoic acid (pPPA) have similar kinetics in circulation, diffusion, and transport. However, pPPA in normal myocardium undergoes beta-oxidation and may also be lost from myocardial cells through back-diffusion; oPPA is hardly catabolized and normally retained mainly in the cytosolic lipid pool. Use of both pPPA and oPPA in the dual-tracer approach focuses observation on the turnover of myocardial lipids (with pPPA) that is scaled against loss of fatty acid through back-diffusion into circulation (with oPPA). Fifteen patients with idiopathic DCM and five control subjects were given oPPA and pPPA sequentially for dynamic planar scintigraphy. Uptake and elimination rates were determined for both substrates from three myocardial regions per individual; the corresponding six elimination rate constants and the three differences between them were analyzed for significant alterations in patients from control values. At least 66% of the patients had a significant alteratio...Continue Reading

References

Jun 1, 1987·The American Journal of Cardiology·J D EisenbergE M Geltman
Sep 1, 1986·Nuclear Medicine Communications·A HöckL E Feinendegen
Jul 1, 1985·Nuclear Medicine Communications·T E BeckurtsL E Feinendegen
Jan 1, 1983·Journal of the American College of Cardiology·R Shabetai
Jan 1, 1981·European Journal of Nuclear Medicine·L E FeinendegenG Stöcklin

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Citations

Apr 2, 2003·Current Atherosclerosis Reports·Briain D MacNeillRoger J Hajjar
Jun 6, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Lisa de las FuentesVictor G Dávila-Román
Jul 11, 2002·Journal of the American College of Cardiology·Víctor G Dávila-RománRobert J Gropler
Dec 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Bryan C BergmanEugene E Wolfel
Aug 9, 2002·European Journal of Heart Failure·Eckart MicheUlrich Gleichmann
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M N SackD P Kelly
Apr 14, 2016·Metabolomics : Official Journal of the Metabolomic Society·James A WestJulian L Griffin
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·John J Lehman, Daniel P Kelly
Dec 12, 2001·Circulation·P RazeghiH Taegtmeyer
Dec 3, 2020·International Journal of Molecular Sciences·Syeda Shegufta AmeerRalph Knöll
Jul 17, 1999·The American Journal of the Medical Sciences·P M Barger, D P Kelly

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