Myocardial mechanical and QTc dispersion for the detection of significant coronary artery disease

European Heart Journal Cardiovascular Imaging
Ivan StankovicAleksandar N Neskovic

Abstract

Ischaemic but viable myocardium may exhibit prolongation of contraction and QT interval duration, but it is largely unknown whether non-invasive assessment of regional heterogeneities of myocardial deformation and QT interval duration could identify patients with significant coronary artery disease (CAD). We retrospectively studied 205 patients with suspected CAD who underwent coronary angiography. QTc dispersion was assessed from a 12-lead electrocardiogram (ECG) as the difference between the longest and shortest QTc intervals. Contraction duration was assessed as time from the ECG R-(Q-)wave to peak longitudinal strain in each of 18 left ventricular segments. Mechanical dispersion was defined as either the standard deviation of 18 time intervals (dispersionSD18) or as the difference between the longest and shortest time intervals (dispersiondelta). Longitudinal strain was measured by speckle tracking echocardiography. Mean contraction duration was longer in patients with significant CAD compared with control subjects (428 ± 51 vs. 410 ± 40 ms; P = 0.032), and it was correlated to QTc interval duration (r = 0.47; P < 0.001). In contrast to QTc interval duration and dispersion, both parameters of mechanical dispersion were inde...Continue Reading

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Citations

Dec 26, 2015·European Heart Journal Cardiovascular Imaging·Victoria Delgado
Jun 6, 2019·The International Journal of Cardiovascular Imaging·Brede KvisvikJørgen Gravning
May 30, 2017·The International Journal of Cardiovascular Imaging·Ivan StankovicAleksandar N Neskovic
Sep 11, 2019·European Heart Journal Cardiovascular Imaging·Erika N AagaardKjetil Steine
Feb 6, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriko MotokiKenichi Koike
Oct 26, 2018·Circulation. Cardiovascular Imaging·Daniel ModinTor Biering-Sørensen
Aug 26, 2018·The International Journal of Cardiovascular Imaging·Inge NoringriisTor Biering-Sørensen
Dec 15, 2020·Intensive Care Medicine Experimental·Kristin Wisløff-AaseAndreas Espinoza
Apr 25, 2021·The Journal of International Medical Research·Xiang JiHuijun Feng

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