PMID: 10651184Jan 29, 2000

Myocardial mechanical restitution and potentiation partly underlie alternans decay of postextrasystolic potentiation: simulation

Heart and Vessels
S MohriH Suga

Abstract

We have reported that the postextrasystolic potentiation (PESP) decays in alternans or monotonically, respectively, depending on whether the first postextrasystolic beat interval has a compensatory pause or not, in the canine left ventricle. To get better mechanistic insight into the alternans PESP decay, we hypothesized that the myocardial mechanical restitution and potentiation could partly account for both types of PESP decay. To test this hypothesis, we simulated PESP decay on a computer using a documented equation combining myocardial mechanical restitution and potentiation. We changed the first postextrasystolic beat interval after a fixed extrasystolic beat interval without changing regular and other postextrasystolic beat intervals. The simulated PESP decayed in alternans or monotonically as a function only of the first postextrasystolic beat interval. Thus, the myocardial mechanical restitution and potentiation could partly account for both alternans and monotonic decay of PESP. We conclude that myocardial mechanical restitution and potentiation may partly underlie the initial two alternating beats, the first beat being the most potentiated and the second beat being the most depressed, of alternans PESP decay in the ca...Continue Reading

References

Aug 1, 1992·Cardiovascular Research·C I SpencerW A Seed
Jun 1, 1988·American Heart Journal·S SchaeferG J Dehmer
Aug 1, 1982·Acta Physiologica Scandinavica·B Wohlfart
Jan 1, 1994·Heart and Vessels·J ArakiH Suga

Citations

Nov 11, 2003·The Japanese Journal of Physiology·J ShimizuH Suga
Mar 26, 2004·The Japanese Journal of Physiology·Masaki TanabeH Suga
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Shunsuke SuzukiH Suga
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S LeeH Suga
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·J MizunoH Suga

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