Myocardial metabolic studies in prolapsing mitral leaflet syndrome.

Circulation
G NatarajanH Goldberg

Abstract

Patients with prolapsing mitral leaflet syndrome (PML) frequently have chest pain of undetermined etiology. Twenty-three patients with PML underwent cardiac hemodynamic, angiographic, and metabolic studies. The latter were performed during control spontaneous heart rate and tachycardia by right atrial pacing. Myocardial supply-demand ratio (DPTI:SPTI) was estimated from the planimetric integration of the diastolic area (diastolic pressure time index = DPTI) and systolic area (systolic pressure time index = SPTI) of the central aortic pressure. Chest pain during pacing occurred in five patients. In two patients, it was associated with ST depression typical of ischemia on the electrocardiogram. Myocardial lactate abnormalities (lactate production or less than 10% extraction) occurred in seven patients during pacing tachycardia and was present in two patients during control state. DPTI:SPTI ratio during control state was 1.22 (+/- 0.07 SE) and decreased to 0.85 (+/- 0.05 SE) during pacing tachycardia. It is concluded that the myocardial lactate abnormalities in PML, which were present in approximately 30% of the patients in the present series, are most likely due to myocardial hypoxia. Whether or not the hypoxia is secondary to "s...Continue Reading

References

May 1, 1972·The American Journal of Cardiology·A S GoochH Goldberg
Oct 10, 1968·The New England Journal of Medicine·W A NeillM P Judkins
Oct 1, 1968·The American Journal of Cardiology·W A Neill
Nov 1, 1962·The Journal of Clinical Investigation·N KRASNOWR GORLIN

❮ Previous
Next ❯

Citations

Oct 1, 1976·The American Journal of Cardiology·N W SalomonN E Shumway
Oct 1, 1983·Journal of the American College of Cardiology·H BoudoulasC F Wooley
Aug 1, 1980·American Heart Journal·A D Malcolm
Nov 1, 1990·Progress in Cardiovascular Diseases·J Chambers, C Bass
Sep 1, 1984·Progress in Cardiovascular Diseases·M H Crawford, R A O'Rourke
Jan 1, 1984·Current Problems in Cardiology·M D Cheitlin, R C Byrd
Nov 1, 1978·The American Journal of Cardiology·G J KleinM J Chamberlain
Oct 1, 1978·The American Journal of Cardiology·J W MasonR A Winkle
Sep 18, 2007·Seminars in Thoracic and Cardiovascular Surgery·Ani C Anyanwu, David H Adams
Apr 1, 1982·Clinical Cardiology·L DeAmbroggiM Radice
Apr 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·G S Hirsowitz, D Saffer
Dec 1, 1980·British Heart Journal·E G Olsen, H K Al-Rufaie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.