PMID: 7544101Aug 1, 1995Paper

Myocardial mitochondrial calcium accumulation modulates nuclear calcium accumulation and DNA fragmentation

The Annals of Thoracic Surgery
E A FaulkSidney Levitsky

Abstract

Previously, we have shown that normothermic global ischemia increases cytosolic calcium accumulation in both the mature and aged heart. Increased nuclear and mitochondrial calcium accumulation was shown to occur in the aged but not the mature heart, and these age-related differences were associated with increased DNA fragmentation and decreased cellular viability only in the aged heart. To investigate the relationship between increased mitochondrial and nuclear calcium and DNA fragmentation, mature and aged rabbit hearts were subjected to normothermic global ischemia with and without the addition of ruthenium red to block mitochondrial calcium influx. Cytosolic calcium accumulation was measured in a parallel experiment using fura-2. Ruthenium red ameliorated mitochondrial calcium accumulation and was associated with both decreased DNA fragmentation and decreased nuclear calcium accumulation. Nuclear calcium accumulation was correlated with increased mitochondrial calcium accumulation but not increased cytosolic calcium accumulation in the aged heart. Modulation of mitochondrion "futile calcium cycling" may be of significance in the modulation of ischemic myocardial injury.

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Citations

Dec 5, 2003·Archives of Biochemistry and Biophysics·James D McCully, Sidney Levitsky
Jul 1, 1996·American Journal of Surgery·I B Krukenkamp, S Levitsky
Feb 28, 2003·The Annals of Thoracic Surgery·James D McCully, Sidney Levitsky
Feb 9, 2002·Burns : Journal of the International Society for Burn Injuries·Liang Wan-YiHuang Yue-Sheng
Mar 20, 2002·Burns : Journal of the International Society for Burn Injuries·Wan-Yi LiangYue-Sheng Huang
Aug 7, 2002·Burns : Journal of the International Society for Burn Injuries·Liang Wan-YIHuang Yue-Sheng
Mar 13, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hidetaka WakiyamaJames D McCully
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A N MurphyG Fiskum
Feb 20, 2013·Antioxidants & Redox Signaling·Natalia GorenkovaAlexander Galkin
Mar 20, 2003·The Annals of Thoracic Surgery·James D McCullySidney Levitsky
Sep 22, 2001·The Annals of Thoracic Surgery·Y ToyodaJ D McCully
May 1, 2016·Clinical and Translational Medicine·James D McCullyDouglas B Cowan
Jul 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Anthony J RousouJames D McCully
Sep 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David L MaassJureta W Horton
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y ToyodaJ D McCully
Sep 30, 1996·Annals of the New York Academy of Sciences·J D McCully, S Levitsky

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