Myocardial oxidative stress, osteogenic phenotype, and energy metabolism are differentially involved in the initiation and early progression of delta-sarcoglycan-null cardiomyopathy.

Molecular and Cellular Biochemistry
Comlan MissihounTeChung Lee

Abstract

Dilated cardiomyopathy (DCM) is a common cause of heart failure, and identification of early pathogenic events occurring prior to the onset of cardiac dysfunction is of mechanistic, diagnostic, and therapeutic importance. The work characterized early biochemical pathogenesis in TO2 strain hamsters lacking delta-sarcoglycan. Although the TO2 hamster heart exhibits normal function at 1 month of age (presymptomatic stage), elevated levels of myeloperoxidase, monocyte chemotactic protein-1, malondialdehyde, osteopontin, and alkaline phosphatase were evident, indicating the presence of inflammation, oxidative stress, and osteogenic phenotype. These changes were localized primarily to the myocardium. Derangement in energy metabolism was identified at the symptomatic stage (4 month), and is marked by attenuated activity and expression of pyruvate dehydrogenase E1 subunit, which catalyzes the rate-limiting step in aerobic glucose metabolism. Thus, this study illustrates differential involvement of oxidative stress, osteogenic phenotype, and glucose metabolism in the initiation and early progression of delta-sarcoglycan-null DCM.

References

Jul 1, 1994·The Journal of Clinical Investigation·A DaughertyJ W Heinecke
Mar 1, 1994·Journal of the American College of Cardiology·E K KasperK L Baughman
Dec 1, 1993·Cardiovascular Research·B C Panchal, N C Trippodo
Aug 1, 1997·Journal of Molecular and Cellular Cardiology·L ThornellD Paulin
Jan 27, 1998·The Journal of Biological Chemistry·T YoshidaM Shigekawa
Feb 10, 1998·Clinical Biochemistry·R H Christenson
Nov 12, 1998·The American Journal of Pathology·E ArbustiniM Viganò
Jan 23, 1999·American Journal of Human Genetics·F M SantorelliM Hirano
Sep 25, 1999·Molecular and Cellular Biochemistry·M MinieriP Di Nardo
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A E StenbitM J Charron
May 3, 2001·Canadian Journal of Physiology and Pharmacology·S GoineauE Bellissant
Nov 22, 2001·JAMA : the Journal of the American Medical Association·R ZhangS L Hazen
Mar 14, 2002·The American Journal of Pathology·Manolis Mavroidis, Yassemi Capetanaki
Jul 19, 2002·Advances in Enzyme Regulation·Robert A HarrisPengfei Wu
Sep 21, 2002·Lancet·Tony ShawWilliam J McKenna
Sep 25, 2002·Physiological Reviews·Diane Fatkin, Robert M Graham
Jan 30, 2003·Trends in Cardiovascular Medicine·Jean-Claude PerriardElisabeth Ehler
Feb 4, 2003·Journal of Lipid Research·A VecchiniP Di Nardo
Apr 25, 2003·Trends in Genetics : TIG·Houman AshrafianHugh Watkins
Oct 3, 2003·Cardiovascular Research·Jay W Mason
Nov 14, 2003·Cardiovascular Research·Laura MasuelliPaolo Di Nardo
Mar 3, 2004·The Journal of Clinical Investigation·Matthew T WheelerElizabeth M McNally
Jul 24, 2004·Circulation Research·Joanne S Ingwall, Robert G Weiss
Oct 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Takao NishizawaMitsuhiro Yokota
Feb 1, 2005·The Journal of Pathology·Roberta FiaccaventoPaolo Di Nardo
Mar 15, 2005·The Journal of Clinical Investigation·Frank J Giordano
Sep 20, 2005·Herz·Bernhard MaischUNKNOWN BMBF-Heart Failure Network
Mar 21, 2006·Biochemical Society Transactions·M S Patel, L G Korotchkina
Jun 13, 2006·Journal of Cardiovascular Electrophysiology·Jeffrey A Towbin, Neil E Bowles
Feb 7, 2007·Biochemical and Biophysical Research Communications·Huey LinTechung Lee
Mar 16, 2007·The New England Journal of Medicine·Stefan Neubauer
Jun 23, 2007·Journal of Molecular and Cellular Cardiology·Maya KhairallahChristine Des Rosiers

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Citations

Jul 31, 2012·American Journal of Physiology. Cell Physiology·Michalis MastriTechung Lee
Apr 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Arsalan ShabbirTechung Lee
Oct 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·David ZisaTechung Lee
Sep 21, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Arsalan ShabbirTechung Lee
Oct 30, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Tatiana F GalvaoWilliam C Stanley
Sep 18, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David ZisaTechung Lee
Mar 26, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Marie-Odile M CheliniRupert Palme
Dec 18, 2013·American Journal of Physiology. Cell Physiology·Michalis MastriTechung Lee
Jun 27, 2009·Molecular and Cellular Biochemistry·Qi-Feng LiuGui-Nan Liu
May 15, 2015·American Journal of Physiology. Cell Physiology·Sean MartinTechung Lee

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