PMID: 6166803Mar 1, 1981Paper

Myocardial oxygen consumption and blood flow during nicotine infusion: effect of combined alpha- and beta-adrenergic blockade

Journal of Cardiovascular Pharmacology
G J CrystalF A Bashour

Abstract

The effect of combined alpha- and beta-adrenergic blockade with phenoxybenzamine and propranolol, respectively, on changes in left ventricular myocardial oxygen consumption and blood flow during nicotine administrations (36 micrograms/kg/min, i.v.) was evaluated in anesthetized, open-chest dogs. Myocardial blood flow was estimated by injection of 8 to 10 micrometers diameter radioactive microspheres into the left atrium, and myocardial oxygen consumption was computed from the Fick principle. Before adrenergic blockade, nicotine caused a market (+151%) elevation in myocardial oxygen consumption and a parallel increase in myocardial blood flow. The increase in myocardial blood flow was uniform transmurally. These cardiac changes were accompanied by elevations in systemic arterial and left atrial pressures, peripheral vascular resistance, and heart rate, but by no change in aortic flow or in myocardial contractility. After adrenergic blockade, nicotine caused somewhat lesser, though still marked, elevations in myocardial oxygen consumption (+60%) and blood flow (+43%). Again, myocardial blood flow increases were uniform transmurally. Also, nicotine-induced increases in systemic arterial and left atrial pressure and in peripheral v...Continue Reading

Citations

Jan 1, 1984·Drug and Chemical Toxicology·J J McGrath, D Smith
Dec 1, 1986·Archives internationales de physiologie et de biochimie·E FurmanJ Kedem
Nov 1, 1983·Stroke; a Journal of Cerebral Circulation·G J CrystalF A Bashour
May 1, 1988·Circulation Research·M A YoungS F Vatner
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·M T Bedran de CastroF A Bashour
Apr 1, 1996·Medicine and Science in Sports and Exercise·J D Symons, C L Stebbins
Dec 3, 2020·European Journal of Sport Science·Andreas M Kasper, Graeme L Close

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