Myocardial Performance Index Determined by Tissue Doppler Imaging in Patients With Systolic Heart Failure Predicts Poor Long-Term Prognosis: An Observational Cohort Study

Journal of Cardiac Failure
Jens OlsonMahbubul Alam

Abstract

Myocardial performance index (MPI) is an echocardiographic parameter that reflects left ventricular (LV) function. MPI determined by means of tissue Doppler imaging (TDI) at different LV sites (global MPI) and its long-term prognostic implications in congestive heart failure (HF) have not been evaluated. A total of 110 patients with HF during acute hospitalization were followed for a mean of 5.0 years for survivors. The myocardial velocities at 4 different LV sites near the mitral annulus from apical views were recorded with the use of pulsed-wave TDI. From myocardial velocity profiles, the MPI at each LV site was calculated: MPI = (isovolumetric contraction time + isovolumetric relaxation time)/ejection time. The global MPI was calculated as the mean from the 4 LV sites. Mean ejection fraction was 25%. A total of 61 patients died during the study period. On multivariate analysis, only MPI emerged as an independent predictor of mortality. With a cutoff value of 0.67, the hazard ratio for cardiovascular mortality during the follow-up period was 13 (95% confidence interval 5.03-34.44; P < .001). A cutoff MPI value of ≥0.67 identified patient mortality during the study period with a sensitivity of 86% and a specificity of 79%. Glo...Continue Reading

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Citations

Dec 11, 2019·Journal of Clinical Medicine·Yannis DimitroglouDimitris Tousoulis
May 21, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·İsa Ardahanlı, Mehmet Celik
May 26, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Aziz KarabulutAlpaslan Kemal Tuzcu
Mar 3, 2019·The International Journal of Cardiovascular Imaging·Gowsini JosephPeter Sogaard
Apr 3, 2021·Frontiers in Cardiovascular Medicine·Tjitske E ZandstraPhilippine Kiès

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