Myocardial perfusion imaging and cardiac events in a cohort of asymptomatic patients with diabetes living in southern France

Diabetic Medicine : a Journal of the British Diabetic Association
A SultanA Avignon

Abstract

To assess the association between abnormal stress myocardial perfusion imaging (MPI) and cardiac events (CE) in asymptomatic patients with diabetes and with > or = 1 additional risk factor. Predictors of abnormal stress MPI were also evaluated. Four hundred and forty-seven consecutive patients who underwent stress MPI were prospectively followed for 2.1 [0.5-4.1] years for the subsequent occurrence of hard CE (myocardial infarction and sudden or coronary death) and soft CE (unstable angina and ischaemic heart failure requiring hospitalization). Re-vascularization procedures performed as a result of the screening protocol were not included in the analysis. Follow-up was successful in 419 of 447 patients (94%), of whom 71 had abnormal MPI at baseline. Medical therapy was intensified in all subjects and especially in those with abnormal MPI. Twenty-three patients with abnormal MPI underwent a re-vascularization procedure. CEs occurred in 14 patients, including six of 71 patients (8.5%) with abnormal MPI and eight of 348 patients (2.3%) with normal MPI (P < 0.005). Only two patients developed a hard CE and 12 a soft CE. In multivariate analysis, abnormal MPI was the strongest predictor for CEs [odds ratio (OR) (95% CI) = 5.6 (1.7-1...Continue Reading

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Citations

Aug 18, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mikael K PoulsenPoul Flemming Høilund-Carlsen
Jun 14, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wanda AcampaAlberto Cuocolo
May 6, 2008·Diabetes Research and Clinical Practice·Jingming BaiAtsushi Kubo
Jun 29, 2010·Diabetes/metabolism Research and Reviews·E MoralidisD P Mikhailidis
Feb 20, 2015·Expert Review of Cardiovascular Therapy·Runqing HuangSharon L Mulvagh
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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