Myocardial perfusion in patients with typical chest pain and normal angiogram

European Journal of Clinical Investigation
S GrafM Zehetgruber

Abstract

Approximately 10-30% of patients with typical chest pain present normal epicardial coronaries. In a proportion of these patients, angina is attributed to microvascular dysfunction. Previous studies investigating whether angina is the result of abnormal resting or stress perfusion are controversial but limited by varying inclusion criteria. Therefore, we investigated whether microvascular dysfunction in these patients is associated with perfusion abnormalities at rest or at stress. In 58 patients (39 female, 19 male, mean age 58+/-10 years) with angina and normal angiogram as well as 10 control patients with atypical chest pain and normal coronaries (six female, four male, mean age 53+/-11 years) myocardial blood flow (MBF) was measured at rest and under dipyridamole using 13N-ammonia PET. Resting MBF and coronary flow reserve (CFR) as the ratio of hyperaemic to resting MBF were corrected for rate-pressure-product (RPP): normalized resting MBF (MBFn)=MBFx10,000/RPP and CFRn=CFRxRPP/10,000. Sixteen/58 patients had a normal CFRn (=2.5; group I; CFRn: 3.1+/-0.88); the same as the controls (CFRn: 3.3+/-0.74). Forty-two/58 patients presented a reduced CFRn (group II; CFRn: 1.78+/-0.57). Group II had both a higher MBFn (group II: 1.30...Continue Reading

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Citations

Jan 9, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni StortoAlberto Cuocolo
Mar 6, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Alberto CuocoloAndrea Soricelli
Jan 22, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·I A C VermeltfoortG J J Teule
Jun 3, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mario PetrettaAlberto Cuocolo
Sep 22, 2011·Nuclear Medicine Communications·George A SayreYoungho Seo
Oct 20, 2015·European Journal of Clinical Investigation·Hiroshi Suzuki
Sep 30, 2018·The International Journal of Cardiovascular Imaging·Andrea G Monroy-GonzalezRene A Tio
Mar 12, 2016·Journal of Nuclear Medicine Technology·Andrew Van ToshKenneth J Nichols

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