Myocardial perfusion scintigraphy with adenosine: does it impair the left ventricular ejection fraction obtained with gated SPECT?

Clinical Nuclear Medicine
Niels BrinkmanMarcel P M Stokkel

Abstract

The aim of this study was to assess whether adenosine impairs left ventricular ejection fraction (LVEF) obtained with gated SPECT in patients with a normal myocardial perfusion scintigram. This prospective study included 160 consecutive patients with a normal myocardial perfusion scintigraphy (MPS), who were stressed with either exercise (n = 64) or with adenosine (n = 96). Student t-test or chi test was used to compare patient's characteristics and functional parameters. Linear regression analyses were used to assess which patient characteristics had an independent significant influence on LVEF. Functional parameters at rest were not significantly different between the adenosine group and the exercise stress group. However at stress, these functional parameters were significantly different. LVEF in the adenosine group decreased by -2.5%, whereas in the exercise group LVEF increased by 2.2% (P = 0.001). Moreover, in 36.5% of the patients a decrease in the LVEF of more than 5% was observed in the group stressed with adenosine compared with 15.6% in the exercise group (P = 0.002). In regression analysis, adenosine (P = 0.001) was selected as an independent significant correlate of a decrease in LVEF. Adenosine seems to impair the...Continue Reading

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Citations

Oct 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiichi OdagiriHideharu Hayashi
May 27, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Berlinda J van der VeenMarcel P M Stokkel
May 3, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Omar S ObeidatMalik E Juweid

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