Myocardial pharmacodynamics of dopamine, dobutamine, amrinone and isoprenaline compared in the isolated rabbit heart

European Journal of Pharmacology
E Vigholt Sørensen, F Nielsen-Kudsk

Abstract

The isolated spontaneously beating rabbit heart was used for comparing the myocardial effects of isoprenaline, dobutamine, dopamine and amrinone. Both isoprenaline and dobutamine produced a progressive concentration-dependent increase in contractility from 100% to a maximum of about 200% (pD2 7.81 and 7.01, respectively) as measured by the increase in isotonic contraction rate. The simultaneous augmentations in contraction amplitude reached maxima of about 127 and 143% (pD2 7.83 and 7.05) for each of the drugs and the heart frequency rose to 202 and 162% (pD2 7.80 and 6.63), respectively. The accompanying oxygen consumption increased from 100 to 194% (pD2 7.70) for isoprenaline and to only 177% (pD2 6.36) for dobutamine. Coronary flow rate rose to 153 and 134%, respectively. Dopamine increased the contraction rate to 181% (pD2 6.26), contraction amplitude to about 122% (pD2 6.25) and heart rate to 162% (pD2, 5.85), while oxygen consumption rose to a maximum of 202% (pD2 5.69). Coronary flow rate rose to 156%. In contrast amrinone produced an unexpected slowly progressing decrease in contraction rate and contraction amplitude to about 66% (pD2 4.45 and 4.01, respectively). Oxygen consumption increased to 159% (pD2 4.10) and coro...Continue Reading

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Citations

Jun 9, 1999·Anesthesiology·P Y GueugniaudB Riou
Jul 1, 1989·Pharmacology & Toxicology·E V Sørensen, O L Pedersen
Dec 10, 1998·British Journal of Pharmacology·L FranquezaJ Tamargo
Oct 12, 1999·The American Journal of Physiology·R J Leor-LibrachE Kaplinsky

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