Myocardial Protection During Aortic Arch Repair in a Piglet Model: Beating Heart Technique Compared With Crystalloid Cardioplegia

The Annals of Thoracic Surgery
Carina JanssenAndré Rüffer

Abstract

Selective myocardial perfusion enables repair of congenital aortic arch obstruction without cardiac arrest. This study was inspired by the lack of prospective controlled studies of the beating heart (BH) technique compared with cold crystalloid cardioplegia (CC) regarding effects on myocardial performance, ischemic damage, and serum electrolyte levels. In a prospective study, 20 male piglets weighing 11.1 ± 1.3 kg were operated on using cardiopulmonary bypass (CPB) and underwent 60 minutes of aortic cross-clamping. According to prospective randomization, myocardial protection included either a BH modification with selective myocardial perfusion using an individual roller pump or CC. Hemodynamic performance was evaluated by a conductance catheter technique before and after CPB and calculated in relation to baseline levels. Laboratory analysis included blood levels of troponin T and serum electrolytes. Eighteen piglets entered analysis. There were significantly higher slopes of end-systolic pressure-volume relations (168% ± 92% versus 89% ± 16%; p = 0.046) and preload-recruitable stroke work (PRSW) (139% ± 37% versus 103% ± 31%; p = 0.040) in BH piglets compared with those who underwent CC. Laboratory analysis during reperfusion ...Continue Reading

References

Jun 1, 1990·The Annals of Thoracic Surgery·S Sano, R B Mee
May 1, 1996·The Annals of Thoracic Surgery·T AsouH Yasui
Jan 1, 1997·Annals of Internal Medicine·R Laureno, B I Karp
Aug 4, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R R ChaturvediC Lincoln
May 18, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·K IshinoS Sano
Feb 1, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Cheong LimChong Whan Kim
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Kozo Ishino, Shunji Sano
Feb 21, 2006·The Annals of Thoracic Surgery·Joachim PhotiadisAndreas E Urban
Jun 16, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gábor SzabóMatthias Karck
Jul 2, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tamás RadovitsGábor Szabó
Apr 30, 2011·The Thoracic and Cardiovascular Surgeon·A RüfferR A Cesnjevar
Jun 12, 2012·Journal of Cardiothoracic Surgery·Gregor LindnerAndrea Lassnigg
May 16, 2013·The Annals of Thoracic Surgery·Joseph W TurekJames E Davis
Sep 7, 2013·Frontiers in Physiology·Geoffrey P DobsonJakob Vinten-Johansen

❮ Previous
Next ❯

Citations

Apr 8, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Matthias Siepe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.