PMID: 7336185Jan 1, 1981Paper

Myocardial protection during aortic valve replacement. Cardiac metabolism and enzyme release following continuous blood cardioplegia

Scandinavian Journal of Thoracic and Cardiovascular Surgery
V BomfimC Olin

Abstract

Cardiac metabolism following hypothermic potassium cardioplegia with blood as cardioplegia vehicle was studied in two groups of patients undergoing aortic valve replacement. In 15 patients, blood was given as single dose infusion (single dose group) and in 18 patients the same initial bolus was followed by a continuous perfusion (25-30 ml/min) with modified blood from the heart-lung machine (continuous blood group). Simultaneous samples were drawn from arterial and coronary sinus blood before and during the first 60 min after cardioplegia. In the continuous blood group, samples were also drawn during the period of cardioplegic perfusion. The samples were analyzed for PO 2, O2-saturation and content, PCO2, pH, lactate, pyruvate, glucose, potassium, myoglobin, creatine kinase (CK), its isoenzyme MB, and aspartate aminotransferase (ASAT). In addition myoglobin and enzymes were followed in peripheral venous blood for 24 hours. Myocardial biopsies were taken from the left ventricle at the beginning and end of cardioplegia and analyzed for adenosine triphosphate (ATP), creatine (C) and creatinephosphate (CP). The pattern of metabolic changes after cardioplegia was similar in both groups with decreased myocardial oxygen extraction, ma...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·C Olin, V Bomfim
Jan 1, 1973·Journal of Neurochemistry·T Kato, O H Lowry
Jun 1, 1972·Journal of Applied Physiology·L KaijserL A Carlson
May 1, 1971·Acta Physiologica Scandinavica·J Karlsson
Jan 1, 1981·Scandinavian Journal of Thoracic and Cardiovascular Surgery·V BomfimC Olin
Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery·V BomfimC Olin

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Citations

Mar 22, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Y TakaharaN Nakajima
Feb 5, 2004·The Annals of Thoracic Surgery·Yves A G LouagieAndré Gruslin
Nov 1, 1983·The Annals of Thoracic Surgery·C L OlinB J Lamke
Mar 1, 1997·The Annals of Thoracic Surgery·Y A LouagieJ C Schoevaerdts
Jun 1, 1984·British Heart Journal·C G McGregorH C Miller
Feb 1, 1991·The Annals of Thoracic Surgery·T A SalernoS V Lichtenstein
Apr 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·W A Lell
Dec 1, 1991·The Annals of Thoracic Surgery·H B Barner
Jan 1, 1993·Perfusion·A L PanosT A Salerno
Jun 1, 1991·Journal of Cardiac Surgery·S V LichtensteinT A Salerno
Jan 1, 1982·Scandinavian Journal of Thoracic and Cardiovascular Surgery·K BöökV Bomfim

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