Myocardial protection in beating heart cardiac surgery: I: pre- or postconditioning with inhibition of es-ENT1 nucleoside transporter and adenosine deaminase attenuates post-MI reperfusion-mediated ventricular fibrillation and regional contractile dysfunction.

The Journal of Thoracic and Cardiovascular Surgery
A S Abd-ElfattahA S Wechsler

Abstract

To determine the role of the p-nitrobenzylthioinosine-sensitive equilibrative nucleoside transporter 1 (es-ENT1) in postmyocardial infarction reperfusion injury-mediated ventricular fibrillation and regional dysfunction. We used erythro-9 (2-hydroxy-3-nonyl)-adenine and p-nitrobenzylthioinosine to inhibit both adenosine deamination and transport in a canine model of off pump acute myocardial infarction. Anesthetized adult dogs (n = 37), instrumented to monitor the percentage of systolic segmental shortening and wall thickening using sonomicrometry, underwent 90 minutes of left anterior descending coronary artery occlusion and 120 minutes of reperfusion. Myocardial coronary blood flow, adenosine triphosphate pool, infarct size, and the incident of ventricular fibrillation and cardioversion were also measured. The dogs received an intravenous infusion of the vehicle (control) or 100 μM of erythro-9 (2-hydroxy-3-nonyl)-adenine and 25 μM p-nitrobenzylthioinosine before ischemia (preconditioning group) or just before reperfusion (postconditioning group). In the control group, adenosine triphosphate depletion was associated with the accumulation of more inosine than adenosine during ischemia and washed out during reperfusion. Myocard...Continue Reading

References

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Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Qing ZhaoJakob Vinten-Johansen
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Jan 20, 2011·Basic Research in Cardiology·Karina GrubeThomas Krieg

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Citations

Jun 17, 2014·Medicinal Research Reviews·Antoni CortésVicent Casadó
Jul 1, 2014·Microvascular Research·Derek B J BoneJames R Hammond
Jan 30, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elodie RobinEric Raddatz

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