PMID: 8911315Nov 1, 1996Paper

Myocardial protection in normal and hypoxically stressed neonatal hearts: the superiority of hypocalcemic versus normocalcemic blood cardioplegia

The Journal of Thoracic and Cardiovascular Surgery
K S BollingH Feinberg

Abstract

The ideal cardioplegic calcium (Ca+2) concentration in newborns continues to be debated. Most studies examining cardioplegia calcium concentrations have been done with a nonclinical model (i.e., isolated heart preparation), the results of which may not be clinically applicable, and they have not examined the effect of calcium concentration in a clinically relevant stressed (hypoxic) heart. Twenty neonatal piglets 5 to 18 days old were placed on cardiopulmonary bypass, and their aortas were crossclamped for 70 minutes with hypocalcemic or normocalcemic multidose blood cardioplegic infusions. Group 1 (n = 5; low Ca+2, 0.2 to 0.4 mmol/L) and group 2 (n = 5; normal Ca+2, 1.0 to 1.3 mmol/L) were nonhypoxic (uninjured) hearts. Ten other piglets were first ventilated at an FiO2 of 8% to 10% (O2 saturation 65% to 70%) for 60 minutes (i.e., causing hypoxia) and then reoxygenated at an FiO2 of 100% with cardiopulmonary bypass, which produces a clinically relevant stress injury. They then underwent cardioplegic arrest (as described above) with a hypocalcemic (n = 5, group 3) or normocalcemic (n = 5, group 4) blood cardioplegic solution. Myocardial function was assessed with pressure volume loops and expressed as a percentage of control va...Continue Reading

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Citations

May 9, 2003·The Annals of Thoracic Surgery·Torsten DoenstFriedhelm Beyersdorf
Jun 26, 2003·The Annals of Thoracic Surgery·Sunil P MalhotraFrank L Hanley
Nov 4, 1998·The Annals of Thoracic Surgery·M KrononS Rahman
Jan 5, 2000·The Annals of Thoracic Surgery·M T KrononM N Ilbawi
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S Allen
Jan 22, 1998·The Journal of Thoracic and Cardiovascular Surgery·M KrononH Feinberg
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C WittnichJ S Ikonomidis
Mar 3, 1998·Journal of the American College of Surgeons·G L Hicks
Oct 4, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·D L SernaJ C Milliken
Jan 1, 2005·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Christian Schlensak
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Bradley S Allen
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·M T KrononM Ilbawi
Jun 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·J E Baker, G N Olinger
Apr 22, 2009·The Annals of Thoracic Surgery·J Darcy O'BrienCamille L Hancock Friesen
Apr 22, 2009·The Annals of Thoracic Surgery·Paul Modi, M Saadeh Suleiman
Sep 28, 2010·The Annals of Thoracic Surgery·Orlando PetrucciPirooz Eghtesady
Jul 26, 2011·The Journal of Thoracic and Cardiovascular Surgery·Xiao-bing LiuJian Zhuang
Aug 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·Arun GovindapillaiStacy B O'Blenes
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Bradley S AllenLouis J Ignarro
Oct 3, 1999·The Journal of Thoracic and Cardiovascular Surgery·M T KrononM Ilbawi
Jul 27, 2010·The Journal of Thoracic and Cardiovascular Surgery·Stacy B O'BlenesSusan Howlett
Apr 22, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Asli Dönmez, Okan Yurdakök
Dec 25, 2019·Interactive Cardiovascular and Thoracic Surgery·Joaquín Pérez-AndreuRaúl F Abella
Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Nina FeirerAlexandro Hoyer
Mar 10, 2001·The Annals of Thoracic Surgery·R P Scott

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