Myocardial protection with leukocyte depletion in cardiac surgery

Seminars in Thoracic and Cardiovascular Surgery
Y Sawa, H Matsuda

Abstract

A role of neutrophils in ischemia-reperfusion injury has been focused on as one of the mediating factors of inflammatory reactions. Current studies have reported the efficacy of leukocyte-depletion in reperfusion by using leukocyte removal filter to attenuate reperfusion injury during open heart surgeries. For clinical application, we have introduced leukocyte-depleted terminal blood cardioplegia (LDTC) in adult patients and leukocyte-depleted blood cardioplegia in pediatric patients. The results of elective surgery in noncompromised LDTC did not significantly alter the results in terms of leakage of creatine kinase (CK)-MB, production of malondialdehyde from myocardium, and dopamine dose required at the weaning from cardiopulmonary bypass compared with the whole-blood reperfusion or with terminal cardioplegia alone. In contrast, the results in emergency coronary artery bypass graft (CABG) patients differed significantly between the LDTC group and the other two groups. Leukocyte-depleted reperfusion was also effective in a similar fashion for patients with severe left ventricular hypertrophy caused by chronic aortic valve disease. Leukocyte-depleted blood cardioplegia was useful in pediatric patients. Thus, leukocyte depletion ...Continue Reading

References

Aug 1, 1977·Journal of Molecular and Cellular Cardiology·D J Hearse
Dec 1, 1990·The Journal of Cell Biology·M S DiamondT A Springer
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Feb 1, 1989·Journal of the American College of Cardiology·M B FormanR Virmani
Jun 1, 1988·Journal of the American College of Cardiology·J L MehtaP Mehta
Jul 1, 1994·The Annals of Thoracic Surgery·K NakanishiJ W Hammon
Dec 1, 1996·The Annals of Thoracic Surgery·F E SchmidtR A Guyton
Jul 13, 2000·The Annals of Thoracic Surgery·Y HayashiH Matsuda

❮ Previous
Next ❯

Citations

Feb 27, 2004·Journal of Clinical Anesthesia·Brian M ParkerJ Michael Henderson
May 1, 2010·Transplantation Proceedings·W H HuangJ Wei
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Manuel CastelláLouis J Ignarro
Jun 24, 2004·Asian Cardiovascular & Thoracic Annals·Norihide FukushimaMotonobu Nishimura
Jan 1, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Bradley Allen, Gerald Buckberg
Jan 21, 2020·Medical Hypotheses·A BarzycA Cudnoch-Jędrzejewska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.