Myocardial regeneration with stem cells: pharmacological possibilities for efficacy enhancement

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Qing-Dong Wang, Per-Ove Sjöquist

Abstract

Cell therapy through the application of stem or progenitor cells to regenerate and repair damaged myocardium has gone from the bench to clinical trial. The functional benefits observed in clinical trials are, however, moderate, and many challenges need to be overcome before cell therapy can be put into widespread clinical use. Better understanding of the signals and molecules that promote cell proliferation, differentiation, engraftment and survival may lead to development of pharmacological agents that enhance the capacity of stem/progenitor cells for myocardial regeneration. The present review will provide a critical analysis of the merits and limitations of different populations of stem/progenitor cells and discuss the potential of pharmacological strategies for enhancing the efficacy of cell therapy for myocardial regeneration.

Citations

Jun 19, 2010·Journal of Cardiovascular Translational Research·Simon MaltaisHung Q Ly
Jul 30, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Frank M Bengel
Nov 14, 2015·Regenerative Medicine·Edmund CarvalhoRinti Banerjee
Apr 26, 2015·Biochemical and Biophysical Research Communications·In-Su ParkJin Chul Ahn
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Lucia FormigliDaniele Bani
Feb 8, 2007·Current Opinion in Cardiology·Rebecca AllanHaissam Haddad
Mar 8, 2019·International Journal of Molecular Sciences·Kyuchang KimSehwan Shim

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