PMID: 22344675Feb 22, 2012Paper

Myocardial remodeling after large infarcts in rat converts post rest-potentiation in force decay

Arquivos brasileiros de cardiologia
Danilo Sales BocaliniPaulo José Ferreira Tucci

Abstract

Post-rest contraction (PRC) of cardiac muscle provides indirect information about the intracellular calcium handling. Our aim was to study the behavior of PRC, and its underlying mechanisms, in rats with myocardial infarction. Six weeks after coronary occlusion, the contractility of papillary muscles (PM) obtained from sham-operated (C, n=17), moderate infarcted (MMI, n=10) and large infarcted (LMI, n=14) rats was evaluated, following rest intervals of 10 to 60 seconds before and after incubation with lithium chloride (Li(+)) substituting sodium chloride or ryanodine (Ry). Protein expression of SR Ca(2+)-ATPase (SERCA2), Na(+)/Ca(2+) exchanger (NCX), phospholamban (PLB) and phospho-Ser(16)-PLB were analyzed by Western blotting. MMI exhibited reduced PRC potentiation when compared to C. Opposing the normal potentiation for C, post-rest decays of force were observed in LMI muscles. In addition, Ry blocked PRC decay or potentiation observed in LMI and C; Li(+) inhibited NCX and converted PRC decay to potentiation in LMI. Although MMI and LMI presented decreased SERCA2 (72±7% and 47±9% of Control, respectively) and phospho-Ser(16)-PLB (75±5% and 46±11%, respectively) protein expression, overexpression of NCX (175±20%) was only obse...Continue Reading

Citations

Dec 25, 2013·BioMed Research International·Tyler SpataAhmet Kilic
Dec 19, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amanda YoshizakiAndrey Jorge Serra
Feb 9, 2021·Journal of Physiology and Biochemistry·Aucélia Cristina Soares BelchiorAlessandra Simão Padilha
Apr 4, 2021·International Journal of Molecular Sciences·Svetlana V KlinovaYuri L Protsenko
Jul 16, 2013·International Journal of Cardiology·Leonardo dos SantosPaulo J F Tucci
Jun 21, 2021·Experimental Physiology·Renata Andrade ÁvilaLeonardo Dos Santos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.