PMID: 25796790Jan 1, 2014Paper

Myocardial remodeling in pediatric congenital cardiac diseases

Revue médicale de Liège
Marie-Christine Seghaye

Abstract

Myocardial remodeling in pediatric congenital cardiac diseases is related to myocardial dysfunction and increases morbidity and mortality. The complex mechanisms that characterize this state involve inflammatory-, growth- and death signaling. The studies we have conducted in infants with hemodynamic overload of the right ventricle, associated or not with hypoxemia, show that mechanical stress related to pressure overload of the right ventricle leads to myocardial expression of pro-inflammatory cytokines such as TNF-α, IL-1β et IL-6, mainly via the activation of p38MAPK signaling. Furthermore, hypoxemia induces activation of the transcription factor HIF-1 that, in turn, induces its target genes VEGF and eNOS. This might be interpreted as an adaptive response. Hypoxemia also contributes to stimulation of growth signaling as it induces CT-1 via the JAK/STAT pathway. The observation that hypoxemia is also associated with a higher degree of troponin T degradation might indicate a loss of the protective function of CT-1 to the myocardium in infants with cyanotic congenital cardiac diseases.

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.