Abstract
We studied the effect of nitroglycerin-induced decreases in mean arterial pressure (MAP) on myocardial salvage. Two hours after occlusion of the left anterior descending coronary artery, 65 conscious dogs were randomly allocated to receive 4 hr intravenous infusions of saline (group 1, 19 dogs), or nitroglycerin in doses to decrease MAP by 10% (group 2, 18 dogs), 25% (group 3, 14 dogs), and 50% (group 4, 14 dogs), respectively. At 7 days, 41 dogs were killed for measurement of infarct size; 24 dogs, given 7 to 10 micron radioactive microspheres for flow calculations, were killed 6 hr after occlusion. Boundaries of the occluded bed were defined by postmortem coronary arteriography. Infarct and occluded bed masses were measured by planimetry of weighed transverse sections of the left ventricle. Compared with saline infusions in group 1, nitroglycerin infusions produced sustained reductions (p less than .001) in mean left atrial pressure and MAP in all dogs, but heart rate was unchanged. The decreases in MAP achieved in groups 2, 3, and 4 were 10% (range, 5% to 19%), 23%, and 39%, respectively, with average levels of 96 (range, 83 to 113), 83, and 64 mm Hg, respectively. Despite similar masses of the occluded bed and left ventricl...Continue Reading
References
Mar 1, 1979·Circulation·J Y Wei, P R Reid
May 4, 1977·The American Journal of Cardiology·N L CapurroS E Epstein
Mar 1, 1978·Circulation·R J Bache
Nov 1, 1979·Circulation·B I JugduttL C Becker
Jan 2, 1975·The New England Journal of Medicine·S E EpsteinD R Redwood
Jan 1, 1975·Circulation·J T FlahertyB Pitt
Jun 1, 1975·The Journal of Clinical Investigation·R J BacheJ C Greenfield
Nov 13, 1975·The New England Journal of Medicine·P C ComeB Pitt
Nov 13, 1975·The New England Journal of Medicine·J S BorerS E Epstein
Jun 1, 1976·British Heart Journal·J T FlahertyB Pitt
Nov 1, 1976·Circulation·M ChiarielloP R Maroko
Nov 1, 1973·The Journal of Clinical Investigation·M V CohenE S Kirk
Jan 1, 1973·Circulation·E R SmithS E Epstein
Aug 1, 1967·Circulation Research·A M Rudolph, M A Heymann
Feb 1, 1971·Circulation Research·L C BeckerB Pitt
Sep 1, 1972·The American Journal of Cardiology·A B WeisseT J Regan
Feb 1, 1972·The American Journal of Cardiology·P R MarokoE Braunwald
Jan 1, 1983·American Heart Journal·F H SheehanS E Epstein
Dec 1, 1983·Circulation·B I JugduttR E Rossall
Jan 1, 1980·The American Journal of Cardiology·E MorcillioB Pitt
Jan 1, 1981·Circulation·B I JugduttC H Kallman
Mar 1, 1981·Circulation·W D BussmannM Kaltenbach
Mar 1, 1981·The Journal of Clinical Investigation·R I LevinK Tack-Goldman
Nov 1, 1981·Prostaglandins and Medicine·B I Jugdutt
Citations
Aug 1, 1994·Cardiovascular Drugs and Therapy·B I Jugdutt
Oct 1, 1990·Cardiovascular Drugs and Therapy·B G Firth, P M Dunnmon
May 23, 1994·European Journal of Pharmacology·P A MartoranaR Henning
May 30, 1996·The American Journal of Cardiology·B I Jugdutt
May 14, 1988·Lancet·S YusufR Peto
Mar 1, 1992·Journal of the American College of Cardiology·B I JugduttM I Khan
Nov 1, 1985·Journal of the American College of Cardiology·B I Jugdutt
Oct 1, 1985·Journal of the American College of Cardiology·J A GaschoG A Beller
Jan 1, 1986·Journal of the American College of Cardiology·B I Jugdutt, R W Amy
Dec 10, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M V MonzaniM Sardina
Aug 13, 1998·Journal of Cardiovascular Pharmacology·R S KhattarA Lahiri
Dec 1, 1995·The Journal of Pharmacy and Pharmacology·A KandaK Kyuki
Nov 1, 1984·British Heart Journal·H IhlenH J Smith
Apr 1, 1995·British Heart Journal·J L MorrisJ C Cowan
Dec 15, 2010·Clinical Interventions in Aging·Bodh I Jugdutt
Feb 27, 2007·Vascular Health and Risk Management·Bodh I Jugdutt
Apr 1, 1990·The American Journal of the Medical Sciences·B G Firth, P M Dunnmon
Apr 14, 2004·Chest·John E Madias
Apr 14, 2004·Chest·John N NanasChristos E Charitos
Nov 24, 2011·Heart Failure Clinics·Bodh I Jugdutt
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Fuminobu IshikuraShintaro Beppu
Nov 1, 1992·American Heart Journal·P HildebrandtJ Jensen
Sep 1, 1986·American Heart Journal·A C NolanP A McElroy
Nov 18, 1991·The American Journal of Cardiology·B I Jugdutt
Apr 1, 1988·Journal of Cardiothoracic Anesthesia·G W MergnerT L Hursey
Sep 24, 1992·The American Journal of Cardiology·B I Jugdutt
Sep 1, 1989·Current Problems in Cardiology·R C Becker, J S Alpert
Dec 16, 1993·The American Journal of Cardiology·B I Jugdutt
Sep 15, 1989·The American Journal of Cardiology·B I Jugdutt, J W Warnica
Nov 1, 1993·The American Journal of Cardiology·V V BonarjeeJ Berning
Feb 15, 2005·Journal of the American College of Cardiology·Takeshi SoekiKenji Kangawa
Jan 1, 1994·Heart and Vessels·B I Jugdutt
Jul 1, 1989·DICP : the Annals of Pharmacotherapy·M F Babich, M L Kalin
Nov 23, 2020·Clinical Transplantation·Leonard NaymagonThomas Schiano
Jan 19, 1987·The Medical Journal of Australia·J D Horowitz, P J Henry