Myocardial sarcomere dynamics during isometric contraction.

The Journal of Physiology
J W Krueger, G H Pollack

Abstract

1. Sarcomere lengths were measured during rest and throughout the time course of isometric contractions in thin, isolated rat papillary muscles using light diffraction techniques. 2. Shortening of the sarcomere length occurred upon contraction at all muscle lengths, averaging 7% at optimal length and more at shorter lengths. Relative to the narrow range of sarcomere lengths spanning the length--tension curve, this degree of shortening was considerable. 3. Local changes of sarcomere length were quantitatively paralleled by local changes of tissue segment length, the latter demarcated by microspheres lodged within the muscle tissue. At all but the shortest muscle lengths, sarcomere shortening was fully accounted for by equivalent lengthening of the non-striated regions near the clamped ends of the preparation. 4. It seems likely that these regions near the clamped ends of the preparation. 4. It seems constitute the source of the large series elasticity characteristic of isolated papillary muscle preparations such as this.

Citations

Dec 10, 2013·Biomechanics and Modeling in Mechanobiology·M CaruelD Chapelle
Mar 21, 2000·Journal of Molecular and Cellular Cardiology·W K WeiwadM H Wussling
May 1, 1986·Medical & Biological Engineering & Computing·G Avanzolini, A Cappello
May 1, 1990·Medical & Biological Engineering & Computing·R Beyar, S Sideman
Jul 1, 1993·Medical & Biological Engineering & Computing·T W TaylorH Suga
Apr 16, 2003·Journal of Biomechanics·Pieter P de Tombe
Oct 1, 1977·Acta Physiologica Scandinavica·B WohlfartK A Edman
Jan 1, 1982·Pharmacology & Therapeutics·B Wohlfart, M I Noble
Jan 5, 2010·Journal of Theoretical Biology·Michael Günther, Syn Schmitt
Mar 5, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Morten SmerupPaul P Lunkenheimer
Jun 1, 1982·IEEE Transactions on Bio-medical Engineering·J MyersG H Pollack
Feb 13, 1999·Journal of Electrocardiology·W F BluhmA D McCulloch
Jan 1, 1991·Journal of Biomechanics·J M HuygheR M Heethaar
Jan 1, 1980·Journal of Biomechanics·R B Panerai
Jan 19, 2016·Global Cardiology Science & Practice·Younss Ait MouPieter P de Tombe
Dec 1, 1988·Journal of the American College of Cardiology·S M FactorT F Robinson
Jul 1, 1976·Nature·P R Housmans, D L Brutsaert
Oct 1, 1982·Pflügers Archiv : European journal of physiology·C PoggesiR Minelli
Dec 1, 1988·Pflügers Archiv : European journal of physiology·M R BoyettC H Orchard
May 18, 1978·Pflügers Archiv : European journal of physiology·P Schiereck, H B Boom
Mar 1, 1983·Pflügers Archiv : European journal of physiology·P J Kil, P Schiereck
May 1, 1991·Circulation Research·M C DanielsH E ter Keurs
Mar 1, 1991·Circulation Research·L E Ford
Mar 1, 1985·Circulation Research·Y LecarpentierP Y Hatt
Jan 1, 1987·Circulation Research·C PoggesiC Reggiani
Jul 1, 1986·Circulation Research·G H Pollack
Jun 1, 1986·Circulation Research·E L de BeerF A van Kaam

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