PMID: 8596694Feb 1, 1996Paper

Myocardial segment shrinkage during coronary reperfusion in situ. Relation to hypercontracture and myocardial necrosis

Pflügers Archiv : European journal of physiology
José A BarrabésJ Soler Soler

Abstract

We have investigated the changes in myocardial segment length induced by reperfusion, and their relation to myocyte hypercontracture and contraction band necrosis. Regional wall function was monitored by ultrasonic gauges in 39 pigs submitted to 48-min occlusion of the left anterior descending coronary artery (LAD) and 6h of reperfusion. Infarct size (triphenyltetrazolium reaction), the extent of contraction band necrosis (quantitative histology) and myocardial water content (desiccation) were measured. Reperfusion induced a marked reduction in end-diastolic length of the LAD segment in all animals, maximal within 15 min after reflow. After 30 min of reperfusion, end-diastolic length of the LAD segment remained below the basal value in 15 animals. The 15 animals that showed shrinkage of the reperfused segment did not differ from the remaining animals in heart rate, aortic pressure, or control segment variables, but had larger infarcts (mean +/- SEM: 32.1 +/- 5.4 vs 12.1 +/- 3.2% of the area at risk, P = 0.003). There was an inverse correlation between end-diastolic length of the LAD segment after 30 min of reperfusion and infarct percentage (r = -0.72) or the extent of contraction band necrosis (r = -0.71). End-diastolic length...Continue Reading

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Citations

Sep 25, 2007·Basic Research in Cardiology·Marisol Ruiz-MeanaDavid Garcia-Dorado
May 16, 2009·Basic Research in Cardiology·Antonio Rodríguez-SinovasDavid García-Dorado
May 29, 2007·Heart Failure Reviews·Antonio Rodríguez-SinovasDavid Garcia-Dorado
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Apr 9, 2009·Cardiovascular Research·Javier InserteDavid Garcia-Dorado
Jun 9, 2009·Cardiovascular Research·David Garcia-DoradoHans Michael Piper
Jul 10, 2010·Cardiovascular Research·Marisol Ruiz-MeanaDavid Garcia-Dorado
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Apr 14, 2012·Cardiovascular Research·David Garcia-DoradoHans Michael Piper
Apr 30, 2014·Revista Española De Cardiología·David Garcia-DoradoJavier Inserte
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Aug 19, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Yazan Bashtawi, Zakaria Almuwaqqat

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