Myocardial sleeves of pulmonary veins and atrial fibrillation: a postmortem histopathological study of 100 subjects.

Virchows Archiv : an International Journal of Pathology
Ivo SteinerIvana Kholová

Abstract

Atrial fibrillation (AF) is triggered by ectopic beats originating from extensions of the left atrial myocardium over the pulmonary veins (PVs), so-called myocardial sleeves. A total of 100 hearts (393 PVs) obtained at autopsy were studied. Of these, 50 were from patients with chronic AF and 50 from controls in sinus rhythm. Out of a total of 393 PVs studied, a sleeve was present in 349 PVs (88.8%). The myocardial sleeves frequently harboured senile atrial amyloid and scarring. These two changes were evaluated semi-quantitatively (grade 0-3). Amyloidosis was found in 68% of all hearts and in 55% of all sleeves. It was more frequent in patients with AF (58.5%) than in those without (51.7%), however, without statistical significance (p values 0.948, 0.306, 0.166 and 1). Scarring was present in all 349 sleeves studied. It was significantly more severe in patients with AF (average grade 2.44) than in those without (average grade 2.00) (p values <0.001, <0.1, <0.05 and <0.01). In conclusion, amyloidosis and particularly scarring of the myocardial sleeves of the pulmonary veins, appear to be common in the elderly population as an arrhythmogenic substrate for AF.

References

May 1, 1986·Journal of Clinical Pathology·G C KayeG Slavin
Dec 1, 1987·The Journal of Pathology·I Steiner
May 1, 1972·British Heart Journal·M J Davies, A Pomerance
Oct 1, 1983·The American Journal of Medicine·G G CornwellP Pitkänen
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D SchubertH Kimura
May 1, 1997·European Heart Journal·M J Janse
Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Oct 6, 2000·Journal of Cardiovascular Electrophysiology·M H HsiehS A Chen
Jan 5, 2001·Pacing and Clinical Electrophysiology : PACE·J B MoubarakJ D Maloney
Feb 7, 2001·Circulation·M A AllessieA L Waldo
Jan 24, 2002·Nature·Stanley Nattel
May 30, 2002·European Journal of Heart Failure·Maarten P van den BergDirk J van Veldhuisen
Jun 14, 2002·Cardiovascular Research·Sawa KostinJutta Schaper
Jun 14, 2002·Cardiovascular Research·Andreas GoetteChristoph Röcken
Aug 15, 2002·Cardiovascular Research·Sander VerheuleJeffrey E Olgin
Oct 16, 2002·Circulation·Christoph RöckenAndreas Goette
Oct 17, 2002·Pacing and Clinical Electrophysiology : PACE·Christian WeissThomas Meinertz
Jun 26, 2003·Pacing and Clinical Electrophysiology : PACE·Ivana Kholová, Josef Kautzner
Aug 9, 2003·The New England Journal of Medicine·Giampaolo Merlini, Vittorio Bellotti
Sep 19, 2003·Journal of the American College of Cardiology·Rutger J HassinkDavid Keane
Feb 12, 2004·Surgical and Radiologic Anatomy : SRA·N RouxP Mertl
Apr 7, 2004·Virchows Archiv : an International Journal of Pathology·Fabio De GiorgioArnaldo Capelli
Jun 15, 2004·Journal of the American College of Cardiology·Michel HaïssaguerreJacques Clémenty
Jun 17, 2004·American Heart Journal·Ole Dyg PedersenChristian Torp-Pedersen
Jun 29, 2004·Virchows Archiv : an International Journal of Pathology·Domenico CorradiOttavio Alfieri
Aug 18, 2004·Circulation·Donald M Lloyd-JonesEmelia J Benjamin
Nov 18, 2004·Pacing and Clinical Electrophysiology : PACE·Simon P Fynn, Jonathan M Kalman
Dec 22, 2004·Journal of Cardiovascular Electrophysiology·Mélèze HociniMichel Haïssaguerre
Jan 29, 2005·Journal of Clinical Pathology·I Kholová, H W M Niessen

❮ Previous
Next ❯

Citations

Nov 3, 2006·Current Treatment Options in Cardiovascular Medicine·Ivana Kholová, Josef Kautzner
Jul 25, 2009·Pharmacology & Therapeutics·Marisa Chard, Reza Tabrizchi
Nov 11, 2011·European Journal of Clinical Investigation·Hsuan-Ming TsaoYi-Jen Chen
Sep 3, 2010·Journal of Cardiovascular Electrophysiology·Nicasio Pérez-CastellanoCarlos Macaya
Mar 26, 2013·Journal of Molecular and Cellular Cardiology·Yen-Yu LuYi-Jen Chen
Jun 21, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Andreas GoetteStanley Nattel
Sep 3, 2016·Journal of Arrhythmia·Andreas GoetteUNKNOWN Review coordinator: Alena Shantsila (UK)
Jul 13, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Andreas GoetteUNKNOWN Document Reviewers:
Jun 23, 2015·The American Journal of Surgical Pathology·Akihiko YoshidaKoji Tsuta
Jul 6, 2020·Journal of Cardiovascular Electrophysiology·Elżbieta SzczepanekMateusz K Hołda
Jul 28, 2019·Current Medical Science·Li-Ya RaoYan-Wen Shu
Jul 20, 2017·G3 : Genes - Genomes - Genetics·Jordan K BoutilierKristen J Nowak
May 24, 2018·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S L SmirnovaS A Kryzhanovskii
Sep 19, 2018·Bulletin of Experimental Biology and Medicine·I M RoshchevskayaS A Kryzhanovskii
Oct 5, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jan-Yow ChenKuan-Cheng Chang
Aug 4, 2021·Indian Journal of Pathology & Microbiology·Saloni Naresh ShahSanjay Theodore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.