Myocardial sparing effect of fentanyl during halothane anaesthesia in dogs.

British Journal of Anaesthesia
J H EiseleC H Miller

Abstract

The cardiovascular effects of fentanyl (Sublimaze) were studied in seven mongrel dogs. A constant infusion of the drug was used to produce an apnoeic end-point while concomitant cardiovascular changes were monitored. After one hour the infusion was repeated while ventilation was controlled and atropine was given to eliminate the haemodynamic effect of changes in PaCO2 and heart rate. When PaCO2 was allowed to increase fentanyl reduced heart rate and mean arterial pressure markedly while left ventricular dp/dt was depressed moderately at the time of respiratory arrest. When heart rate and PaCO2 were kept constant there was little variation in the cardiovascular measurements during fentanyl infusion. We conclude that fentanyl allows relative myocardial sparing in dogs when used at clinically effective concentrations.

Citations

Jul 1, 1991·Medicinal Research Reviews·J R BagleyM H Ossipov
May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·K InoueJ O Arndt
Jul 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A CoetzeeE Badenhorst
May 24, 2005·Journal of Pain and Symptom Management·Theodore H Stanley
Jan 1, 1977·Acta Anaesthesiologica Scandinavica. Supplementum·E L Maunuksela
Aug 2, 2013·The Journal of Small Animal Practice·P P TsompanidouT L Anagnostou
Apr 1, 1984·Acta Anaesthesiologica Scandinavica·B LindströmO Stenqvist
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Jun 15, 2000·The Veterinary Clinics of North America. Small Animal Practice·S Z Perkowski
Feb 1, 1987·Anaesthesia and Intensive Care·T H Stanley

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