PMID: 11922113Apr 2, 2002Paper

Myocardial stereological adaptations in wistar rats fed with different high-fat diets during 18 months

Journal of Nutritional Science and Vitaminology
Marcia Barbosa Aguila, C A Mandarim-de-Lacerda

Abstract

This study has the purpose of investigating the influence of different high-fat experimental diets on myocardial structure in rats. Twenty-seven male rats were fed from 21 d old (postnatal age) until 18 mo old with one of the following supplemented diets: soybean oil (S) (n= 6), canola oil (CA) (n= 8), or lard and egg yolk (LE) (n= 6) or canola oil+ lard and egg yolk (CA+LE) (n=7). The blood pressure (BP) was measured, and after the sacrifice the cardiac biometry and the myocardial stereology were determined: cross-sectional area of cardiomyocyte (A), volume density (Vv), surface density (Sv), and length density (Lv) in relation to the cardiomyocytes (cm), connective tissue (ct), and blood vessels (v). The CA group rats had lower BP, A[cm], and Vv[ct]; they had greater Vv[cm], Sv[cm], Vv[v], Lv[v], and Sv[v] than the other groups. The S rats had intermediary values for the myocardium and blood vessel parameters between the CA and LE group rats. These results support the notion that the long-term use of canola oil in the diet is better to preserve the myocardium structure, including microvascularization, than soybean oil or lard and egg yolk.

Citations

Apr 20, 2005·International Journal of Cardiology·Marcia B AguilaCarlos A Mandarim-de-Lacerda
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Apr 8, 2003·Nutrition·Marcia B Aguila, Carlos Alberto Mandarim-de-Lacerda
Nov 19, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marcia Barbosa Aguila, Carlos Alberto Mandarim-De-Lacerda
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Byung Hee KimCasimir C Akoh
Aug 24, 2010·Journal of Medicinal Food·Byung Hee KimBoo-Yong Lee
Jan 5, 2007·Clinical and Experimental Pharmacology & Physiology·Isidore C OkereWilliam C Stanley
Jan 8, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Márcia Barbosa AguilaCarlos Alberto Mandarim-de-Lacerda

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