Myocardial Stress Perfusion MRI: Experience in Pediatric and Young-Adult Patients Following Arterial Switch Operation Utilizing Regadenoson

Pediatric Cardiology
Cory V NoelRajesh Krishnamurthy

Abstract

Dextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardial perfusion assessment within ASO patients. There is no report on the utility of regadenoson as a stress agent in children following ASO. Our objective was to observe the safety and feasibility of regadenoson as a pharmacologic stressor for perfusion cardiac MR in a pilot cohort of pediatric and young-adult patients who have undergone ASO. We reviewed our initial experience with regadenoson stress cardiac MR in 36 pediatric and young-adult patients 15.1 ± 4.5 years (range 0.2-22 years) with history of ASO. The weight was 61.6 ± 21.5 kg (range 3.8-93 kg). All patients underwent cardiac MR because of concern for ischemia. Subjects' heart rate and blood pressure were monitored and pharmacologic stress was induced by injection of regadenoson. We evaluated their hemodynamic response and adverse effects using changes in vital signs and onset of symptoms. A pediatric cardiologist and radiologist qualitatively assessed my...Continue Reading

References

May 20, 1999·Journal of the American College of Cardiology·E D BlumeT Geva
Jun 28, 2001·The Annals of Thoracic Surgery·J W BrownM W Turrentine
Apr 26, 2003·International Journal of Cardiology·Michael A Gatzoulis, Thomas P Graham
Aug 3, 2007·Heart, Lung & Circulation·Sharon H WongThomas L Gentles
Sep 19, 2009·Journal of the American College of Cardiology·Wael Al Jaroudi, Ami E Iskandrian
Dec 2, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Emanuela R Valsangiacomo BuechelJuerg Schwitter
Feb 16, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Olivier MettonPascal R Vouhé
May 11, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hong-Gook LimYong Jin Kim
Jul 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·Phalla OuDamien Bonnet
Aug 14, 2012·International Journal of Cardiology·Aleksander KempnyGerhard-Paul Diller
Sep 26, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Sujethra VasuAndrew E Arai
Jan 24, 2014·European Heart Journal Cardiovascular Imaging·Kim-Lien NguyenAndrew E Arai
Aug 2, 2014·Journal of the American College of Cardiology·Juan VillafañeUNKNOWN American College of Cardiology’s Adult Congenital and Pediatric Cardiology Council
Dec 17, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Daniel ToblerAndrew M Crean
Aug 6, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Nico H J Pijls, Lokien X van Nunen
Oct 17, 2015·Cardiology Clinics·Christiane Haeffele, George K Lui
Jul 28, 2016·European Heart Journal Cardiovascular Imaging·Hopewell N NtsinjanaAndrew M Taylor

❮ Previous
Next ❯

Citations

Dec 9, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Suvipaporn Siripornpitak, Hyun Woo Goo
Aug 4, 2020·The Journal of Thoracic and Cardiovascular Surgery·Viktor Hraska, Benjamin H Goot
Oct 31, 2019·Radiology. Cardiothoracic Imaging·James C WilkinsonCory V Noel
Jul 11, 2021·Pediatric Cardiology·Jeffrey A HutchensR Mark Payne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Olivier RaiskyPascal R Vouhé
Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Milad El-SegaierErkki Pesonen
© 2022 Meta ULC. All rights reserved