Myocardial substrate utilization and hemodynamics following repeated coronary flow reduction in pigs

Basic Research in Cardiology
P D VerdouwW A Breeman

Abstract

The effect of repeated local ischemia and reperfusion on myocardial metabolism and ventricular performance was studied in 12 open-chested pigs fasted overnight. Myocardial ischemia was induced by reduction of the flow in the left anterior descending coronary artery to 40% of control during 30 min. After 35 min of reperfusion a second 30-min occlusion period was started, again followed by a 35-min reperfusion period. At the end of both reperfusion periods coronary flow and coronary resistance had returned to control values. During control there was lactate uptake, but no significant uptake of glucose, free fatty acids (FFA), triglycerdies, glycerol and inosine. During the first occlusion period the heart released lactate and inosine, and used glucose and FFA. At the end of the first reperfusion period lactate uptake approached control values, but inosine was still released by 10 of the 12 animals. In the second ischemic period, glucose and FFA were again taken up. Lactate and inosine were released, but the production was much smaller than during the first occlusion period. Depletion of myocardial glycogen and high-energy phosphates could be responsible for this quantitatively different response. Necrosis may have played a role, ...Continue Reading

References

Dec 1, 1975·Circulation Research·M J RovettoJ R Neely
Dec 28, 1976·Pflügers Archiv : European journal of physiology·J Schrader, E Gerlach
Jul 1, 1978·Journal of Molecular and Cellular Cardiology·C SteenbergenJ R Williamson
Feb 1, 1978·The American Journal of Cardiology·R J Capone, A S Most
May 1, 1977·Cardiovascular Research·A S MostP A Mastrofrancesco
Dec 1, 1975·The American Journal of Physiology·K Ichihara, Y Abiko
Feb 1, 1975·The American Journal of Physiology·A J LiedtkeJ R Neely
Nov 1, 1975·The American Journal of Cardiology·H BrooksL Resnekov
Mar 31, 1976·The American Journal of Cardiology·N Brachfeld
Nov 1, 1970·Analytical Biochemistry·C S ApsteinN Brachfeld
Sep 1, 1974·Circulation Research·D E Gregg
May 1, 1972·Cardiovascular Research·P F CohnC W Urschel
Sep 1, 1954·Circulation Research·R W ECKSTEIN

Citations

Jul 1, 1998·Progress in Cardiovascular Diseases·K Przyklenk, R A Kloner
Oct 1, 1988·British Journal of Pharmacology·L M SassenP D Verdouw
Mar 7, 1989·The American Journal of Cardiology·P W SerruysJ W de Jong
Apr 1, 1982·American Heart Journal·H R SchelbertD E Kuhl
Sep 25, 2003·British Journal of Anaesthesia·Michael ZauggMarcus C Schaub
Aug 4, 2007·Journal of Applied Physiology·David A LiemPeipei Ping

Related Concepts

Metazoa
Blood Glucose
Coronary Circulation
Nonesterified Fatty Acids
Glycerin
Hemodynamics
Inosine
Lactates
Myocardium
Dioxygen

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