PMID: 9420728Sep 1, 1994Paper

Myocardial technetium 99m-labeled sestamibi single-photon emission computed tomographic imaging in the detection of coronary artery disease: comparison between early (15 minutes) and delayed (60 minutes) imaging

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
R TailleferD C Phaneuf

Abstract

Previous studies have demonstrated that there is a "partial" myocardial redistribution of 99mTc-labeled sestamibi (MIBI) between 1 and 3 hours after intravenous injection at stress. The purpose of this prospective study was to compare MIBI single-photon emission computed tomographic (SPECT) imaging performed 15 and 60 minutes after the injection at stress in the detection of coronary artery disease. Thirty-five patients with coronary artery disease (26 underwent coronary angiography and 23 had a positive 201Tl study result) were included in this study. SPECT imaging started 15 minutes after the injection of 25 to 30 mCi MIBI at peak stress (180-degree arc, 32 angles, 25 sec/view, and high-resolution collimator). Patients underwent reimaging at 60 minutes according to the same protocol and with the same gamma camera. A rest study was obtained 75 minutes after the injection of MIBI (25 to 30 mCi) at rest, 48 hours later. Images (divided for a total of 19 segments per patient) were interpreted by two blinded observers for patient diagnosis and segmental comparison. The patient diagnosis was the same for the two protocols: normal = 3, ischemia = 27, and scar = 5. The segmental agreement (kappa = 0.90) was 632/665 (95.0%). The imagi...Continue Reading

References

Feb 1, 1990·Circulation·D K Glover, R D Okada
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Citations

Apr 4, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Aiden AbidovDaniel S Berman
Jul 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R C HendelM C Gerson
Sep 13, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Raymond Taillefer
Apr 6, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Raymond Taillefer
Apr 22, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Celine Meyer, Pierre Weinmann
Feb 22, 2012·Critical Reviews in Toxicology·John M DeSessoMark E Hurtt

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