PMID: 9420717Jul 1, 1994Paper

Myocardial technetium 99m-labeled teboroxime clearance derived from canine scans differentiates severity of stenosis after dipyridamole

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
G JohnsonR D Okada

Abstract

The purposes of this study were to determine (1) whether perfusion defects and differential teboroxime clearance observed on serial postdipyridamole planar gamma camera images have utility in differentiating severity of coronary stenosis in canine myocardium and (2) whether single-zone (99mTc activity in one zone over time) or dual-zone (99mTc activity ratio in two zones over time) quantitative analysis provides the most useful characterization of teboroxime clearance kinetics. Accordingly, eight dogs received a mild coronary stenosis (microsphere-determined, post-dipyridamole flow > or = 0.4 ml/min/gm) and 10 dogs received a severe coronary stenosis (flow < or = 0.3 ml/min/gm). In three control dogs there was no coronary stenosis. Teboroxime (5 mCi) was injected after dipyridamole (0.8 mg/kg/min), and gamma camera imaging was begun immediately and continued for 60 minutes. Quantitative analysis of single-zone clearance curves indicated that teboroxime retention for both zones of stenosis (mild = 66.3% +/- 2.8%, SEM; severe = 69.5% +/- 3.7%) was significantly greater than control zone retention (54.5% +/- 3.0%; p < 0.05) at 10 minutes. Retention in mild (37.2% +/- 1.9%, SEM) and severe (42.3% +/- 1.5%) zones of stenosis was sig...Continue Reading

References

Sep 1, 1992·Journal of the American College of Cardiology·R BeanlandsM Schwaiger
Mar 1, 1992·Clinical Nuclear Medicine·W E DraneM Nicole
Apr 1, 1993·The American Journal of Cardiology·H WeinsteinJ A Leppo

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Citations

May 5, 2000·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A J Sinusas
Jan 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R J Burns
May 1, 1997·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G JohnsonR D Okada
Jan 15, 2002·Cardiology Clinics·F G Blankenberg, H W Strauss

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