Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: experiments and modelling.

The Journal of Physiology
J-C HanD S Loiselle

Abstract

We tested the proposition that linear length dependence of twitch duration underlies the well-characterised linear dependence of oxygen consumption (V(O(2)) ) on pressure–volume area (PVA) in the heart. By way of experimental simplification, we reduced the problem from three dimensions to one by substituting cardiac trabeculae for the classically investigated whole-heart. This allowed adoption of stress–length area (SLA) as a surrogate for PVA, and heat as a proxy for V(O(2)) . Heat and stress (force per cross-sectional area), at a range of muscle lengths and at both 1 mM and 2 mM [Ca(2+)](o), were recorded from continuously superfused rat right-ventricular trabeculae undergoing fixed-end contractions. The heat–SLA relations of trabeculae (reported here, for the first time) are linear. Twitch duration increases monotonically (but not strictly linearly) with muscle length. We probed the cellular mechanisms of this phenomenon by determining: (i) the length dependence of the duration of the Ca(2+) transient, (ii) the length dependence of the rate of force redevelopment following a length impulse (an index of Ca(2+) binding to troponin-C), (iii) the effect on the simulated time course of the twitch of progressive deletion of length...Continue Reading

References

Mar 1, 1979·The American Journal of Physiology·H Suga
Nov 1, 1979·The American Journal of Physiology·F KhalafbeiguiK Sagawa
Feb 1, 1976·Circulation Research·F J Julian, R L Moss
Apr 1, 1992·The American Journal of Physiology·T WannenburgD Burkhoff
Mar 1, 1991·The American Journal of Physiology·J N PetersonM R Berman
Apr 1, 1990·Physiological Reviews·H Suga
Jul 1, 1987·The American Journal of Physiology·P A Hofmann, F Fuchs
Apr 1, 1988·Journal of Applied Physiology·H A Feldman
Aug 1, 1988·The American Journal of Physiology·Y GotoM M LeWinter
Aug 1, 1985·The American Journal of Physiology·C L Gibbs, J B Chapman
Jul 1, 1971·Cardiovascular Research·A J Brady
Mar 1, 1982·The American Journal of Physiology·R van HeuningenH E ter Keurs
Aug 1, 1995·The American Journal of Physiology·P M Janssen, W C Hunter
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology·C L Gibbs
Sep 1, 1993·The American Journal of Physiology·D BurkhoffW C Hunter
Mar 1, 1993·The American Journal of Physiology·T W TaylorH Suga
May 1, 1996·Journal of Molecular and Cellular Cardiology·J A Negroni, E C Lascano
Dec 15, 1995·The Journal of Physiology·S Kurihara, K Komukai
Feb 12, 1998·The American Journal of Physiology·T KameyamaM M LeWinter
Mar 10, 1999·The American Journal of Physiology·A Landesberg, S Sideman
Sep 13, 2000·Annals of Biomedical Engineering·M VendelinD H van Campen
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T TsujiM Takaki
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Juichiro ShimizuDaniel Burkhoff
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey W HolmesGerd Hasenfuss
Aug 15, 2002·Cardiovascular Research·Tharumenthiran RamanathanStephen Hunyor
Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kai HuGeorg Ertl
Nov 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yoshiro YoshikawaMiyako Takaki
Mar 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ole-Jakob HowTerje S Larsen
Nov 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·István Ferenc EdesZoltán Papp
Feb 16, 2007·Journal of Molecular and Cellular Cardiology·Susumu SakataRoger J Hajjar

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Citations

Jun 12, 2013·Clinical and Experimental Pharmacology & Physiology·Soyeon GooDenis Loiselle
Sep 19, 2012·The Journal of Physiology·Nicolas P SmithDavid J Paterson
Jun 3, 2016·Computers in Biology and Medicine·Jing Jin ShenWen An Yang
May 24, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Callum M JohnstonAndrew J Taberner
Mar 27, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Callum M JohnstonAndrew J Taberner
Mar 23, 2021·Progress in Biophysics and Molecular Biology·Denis S LoiselleJune-Chiew Han

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