Myocardial ultrasonic tissue characterization in pediatric and adult patients with hypertrophic cardiomyopathy

Circulation
D F VitaleF Rengo

Abstract

Hypertrophic cardiomyopathy (HCM) has different clinical and prognostic aspects in young than in adult patients. This study was undertaken to determine whether these reported differences are reflected by changes in ultrasonic backscatter parameters and whether oral treatment with verapamil modifies backscatter variables in children with HCM. Sixty-eight subjects underwent backscatter analysis to assess the ultrasonic myocardial reflectivity and the amplitude of the cardiac cycle-dependent variation of the backscatter power curve. Subjects were divided into four groups: 10 HCM and 23 normal subjects < 10 years old and 17 HCM and 18 normal adults. Myocardial reflectivity and amplitude of the cyclic variation were assessed in the septum and in the posterior wall of all subjects. The children with HCM were restudied after long-term oral administration of verapamil. Both children and adult patients, compared with the normal control groups, showed a significant reduction in the amplitude of the cyclic variation both in the septum and in the posterior wall. In contrast, myocardial reflectivity, although significantly increased in adult HCM patients, was unchanged in the young HCM group. Verapamil administration did not significantly a...Continue Reading

References

Apr 1, 1991·Journal of the American College of Cardiology·F LattanziA L'Abbate
Aug 1, 1989·Journal of the American College of Cardiology·M R MilunskiS A Wickline
Jan 1, 1988·Journal of the American College of Cardiology·W J McKennaJ E Deanfield
Feb 1, 1988·The Journal of the Acoustical Society of America·E I MadarasJ G Miller
Apr 1, 1980·The American Journal of Cardiology·B W GilbertE D Wigle
Jul 1, 1983·Ultrasonic Imaging·E I MadarasJ G Miller
Mar 1, 1983·The American Journal of Cardiology·A K Bhandari, N C Nanda
Feb 1, 1981·The Journal of the Acoustical Society of America·M O'DonnellJ G Miller

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Citations

Sep 20, 2005·International Journal of Cardiology·Tomoya KanedaHiroshi Mabuchi
Feb 1, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Giovanni Di SalvoRaffaele Calabrò
Apr 13, 2011·The American Journal of Cardiology·Barry J MaronMartin S Maron
Jan 8, 2000·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A E Finch-JohnstonJ G Miller
Jul 14, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Maria-Angela LosiMassimo Chiariello
Sep 3, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Tatsuya KawasakiHiroki Sugihara
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giuliana LamaMaria Esposito-Salsano

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