PMID: 9420718Jul 1, 1994Paper

Myocardial uptake of thallium 201 and technetium 99m-labeled sestamibi after ischemia and reperfusion: comparison by quantitative dual-tracer autoradiography in rabbits

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
H WeinsteinJ A Leppo

Abstract

Myocardial scintigraphy with 99mTc-labeled sestamibi (99mTc-sestamibi) or 201Tl is used to assess regional perfusion in acute coronary syndromes associated with metabolic or functional abnormalities, such as acute coronary thrombosis with reperfusion and ischemia at rest. However, the initial uptake of these agents may be affected by a recent ischemic insult because the myocardial retention of these tracers depends on cellular metabolism. Accordingly, 99mTc-sestamibi and 201Tl were injected simultaneously in rabbits after transient brief (10 to 15 minutes, group I) or prolonged (45 to 60 minutes, group II) coronary occlusion. Accumulated subendocardial and subepicardial 99mTc-sestamibi and corresponding 201Tl activity were determined from autoradiographs of 30 microns short-axis slices comounted with serial tissue standards. Circumferential 99mTc-sestamibi and 201Tl activity profiles closely overlapped in both groups. The initial global and segmental myocardial activity per unit blood flow within the ischemic zone did not differ from unity for either tracer regardless of the duration of the ischemic insult. The initial myocardial uptake of both 99mTc-sestamibi and 201Tl after an acute ischemic insult reflected predominantly cor...Continue Reading

References

Nov 1, 1976·Cardiovascular Research·J M WeinerW B Hood
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·T Ito, A B Brill
Sep 1, 1990·Circulation·R Bolli
Sep 1, 1989·Japanese Heart Journal·T MiuraO Iimura
Jan 1, 1986·The Journal of Clinical Investigation·D C HomansR J Bache
Apr 1, 1983·International Journal of Radiation Oncology, Biology, Physics·G P GlasgowW B Mill
Dec 1, 1983·Journal of the American College of Cardiology·W S RobertsonP W McHenry
May 1, 1984·Journal of the American College of Cardiology·R D Okada
Jan 1, 1983·Medical Physics·P C Johns, M J Yaffe

❮ Previous
Next ❯

Citations

Nov 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R ValkemaE E van der Wall
Oct 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Zhonglin LiuRobert D Okada
May 20, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A J Sinusas
Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yoshihiro J AkashiMaciej Banach
Sep 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Takahiro HiguchiMarkus Schwaiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.