PMID: 11923039Mar 30, 2002Paper

Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis

Journal of the American College of Cardiology
Kevin C AllmanJames E Udelson

Abstract

This study pools data from published series examining late survival with revascularization versus medical therapy after myocardial viability testing in patients with severe coronary artery disease (CAD) and left ventricular (LV) dysfunction. Previous observational studies have suggested survival benefit in such patients if they are revascularized when myocardial viability is detected on imaging tests. A MEDLINE database search returned 24 viability studies reporting patient survival using thallium perfusion imaging, F-18 fluorodeoxyglucose metabolic imaging or dobutamine echocardiography. Annual death rates were extracted, pooled and analyzed with a random effects model. The risk-adjusted relationship between severity of LV dysfunction, presence of viability and survival benefit associated with revascularization was assessed by meta-regression. There were 3,088 patients (2,228 men), ejection fraction 32 +/- 8%, followed for 25 +/- 10 months. In patients with viability, revascularization was associated with 79.6% reduction in annual mortality (16% vs. 3.2%, chi-square = 147, p < 0.0001) compared with medical treatment. Patients without viability had intermediate mortality, trending to higher rates with revascularization versus m...Continue Reading

References

Dec 1, 1986·Journal of the American College of Cardiology·E Braunwald, J D Rutherford
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Apr 15, 1995·The American Journal of Cardiology·G GioiaA S Iskandrian
Jan 1, 1996·Journal of the American College of Cardiology·M J WilliamsT H Marwick
Mar 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G GioiaA S Iskandrian
Jun 18, 1998·American Heart Journal·M GheorghiadeR O Bonow
Nov 18, 2000·The New England Journal of Medicine·G A Beller

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Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Antti SarasteMarkus Schwaiger
Dec 3, 2003·European Journal of Nuclear Medicine and Molecular Imaging·S F BarringtonT O Nunan
Apr 13, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Allan JohansenTorben Haghfelt
May 17, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Alberto Cuocolo
Dec 21, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Anna Rita SorrentinoAlberto Cuocolo
Dec 24, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Stephan G NekollaAntti Saraste
Aug 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Raffaele GiubbiniMaurizio Dondi
Apr 27, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Marco SpadaforaAlberto Cuocolo
Feb 3, 2007·European Radiology·Andreas H MahnkenJoachim E Wildberger
Mar 27, 2012·European Radiology·Dennis T L WongStephen G Worthley
Apr 25, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Paul Knaapen, Mark Lubberink
Jan 12, 2007·The International Journal of Cardiovascular Imaging·Brian J SchietingerChristopher M Kramer
Jan 22, 2010·The International Journal of Cardiovascular Imaging·Johannes BoehmRüdiger Lange
May 24, 2005·Cell and Tissue Banking·M Esther Rendal VázquezF J Blanco Garcia
Nov 30, 2006·Heart Failure Reviews·Frank M Bengel
Aug 29, 2006·Heart Failure Reviews·Roxy Senior
Nov 27, 2008·Current Heart Failure Reports·Marzia LeaccheJohn G Byrne
Mar 7, 2009·Current Heart Failure Reports·Bodh I Jugdutt
Dec 2, 2009·Current Heart Failure Reports·Farouk Mookadam, Sherif E Moustafa
Dec 14, 2011·Current Heart Failure Reports·Juan A Crestanello
Oct 22, 2013·Current Heart Failure Reports·Saurabh JhaDeborah H Kwon
Jul 2, 2003·Current Treatment Options in Cardiovascular Medicine·James O. O'Neill, Randall C. Starling
Nov 15, 2005·Current Treatment Options in Cardiovascular Medicine·Edwin C McGeePatrick M McCarthy
Sep 11, 2013·Current Treatment Options in Cardiovascular Medicine·Robert Michler
Apr 3, 2013·Annals of Nuclear Medicine·Ryogo MinamimotoKazuo Kubota
Mar 1, 2009·Journal of Cardiovascular Translational Research·Peter J Psaltis, Stephen G Worthley
Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Laura EvangelistaAlberto Cuocolo
Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Prem SomanJames E Udelson
Feb 10, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Prem Soman
Nov 11, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James A FallavollitaJohn M Canty
Feb 27, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Fadi G HageAmi E Iskandrian
Mar 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Randolph E PattersonRobert L Eisner
Apr 10, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yoichi InabaSteven R Bergmann
Jul 10, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·George A Beller
Jun 15, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Aju P PazhenkottilPhilipp A Kaufmann
Sep 14, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert O Bonow, Thomas A Holly
Dec 2, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Iosif Kelesidis, Mark I Travin
Feb 14, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E Gordon DepueyL Samuel Wann
Jun 19, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kevin C Allman
Aug 31, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vinay GulatiGary V Heller
Apr 10, 2009·JACC. Cardiovascular Imaging·Shahbudin H RahimtoolaJean-Louis J Vanoverschelde

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