Myocardial Work in Nonobstructive Hypertrophic Cardiomyopathy: Implications for Outcome.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Yasmine L HiemstraNina Ajmone Marsan

Abstract

Noninvasive left ventricular (LV) pressure-strain loop analysis is emerging as a new echocardiographic method to evaluate LV function, integrating longitudinal strain by speckle-tracking analysis and sphygmomanometrically measured blood pressure to estimate myocardial work. The aims of this study were (1) to describe global and segmental myocardial work in patients with hypertrophic cardiomyopathy (HCM), (2) to assess the correlation between myocardial work and other echocardiographic parameters, and (3) to evaluate the association of myocardial work with adverse outcomes. One hundred ten patients with nonobstructive HCM (mean age, 55 ± 15 years; 66% men), with different phenotypes (apical, concentric, and septal hypertrophy), and 35 age- and sex-matched healthy control subjects were included. The following myocardial work indices were included: myocardial work index, constructive work (CW), wasted work, and cardiac efficiency. The combined end point included all-cause mortality, heart transplantation, heart failure hospitalization, aborted sudden cardiac death, and appropriate implantable cardioverter-defibrillator therapy. Mean global CW (1,722 ± 602 vs 2,274 ± 574 mm Hg%, P < .001), global cardiac efficiency (93% [89%-95%] v...Continue Reading

Citations

Nov 20, 2020·The International Journal of Cardiovascular Imaging·Letizia SpinelliGiovanni Esposito
Nov 22, 2020·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Frank A Flachskampf
Jan 1, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ryota EbataMark K Friedberg
Mar 24, 2021·Current Problems in Cardiology·Daniela Di LisiGiuseppina Novo
Apr 4, 2021·Diagnostics·Konstantinos PapadopoulosIgnatios Ikonomidis
Apr 26, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sarah RoemerBijoy K Khandheria
Jun 26, 2021·Cardiovascular Ultrasound·Qiancheng LiLina Sun
Jul 6, 2021·Frontiers in Cardiovascular Medicine·Felix HedwigJan Knierim
Jun 29, 2021·Frontiers in Cardiovascular Medicine·Floran SahitiStefan Störk
Jun 23, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Clemence RioletSylvestre Marechaux
Aug 1, 2021·Journal of Cardiac Failure·Floran SahitiStefan Störk

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