Myocarditis in patients with subarachnoid hemorrhage: A histopathologic study

Journal of Critical Care
I A C van der BiltHans W M Niessen

Abstract

Cardiac abnormalities after subarachnoid hemorrhage (SAH) such as electrocardiographic changes, echocardiographic wall motion abnormalities, and elevated troponin levels are independently associated with a poor prognosis. They are caused by catecholaminergic stress coinciding with influx of inflammatory cells into the heart. These abnormalities could be a sign of a myocarditis, potentially giving insight in pathophysiology and treatment options. These inflammatory cells are insufficiently characterized, and it is unknown whether myocarditis is associated with SAH. Myocardium of 25 patients who died of SAH and 18 controls was stained with antibodies identifying macrophages (CD68), lymphocytes (CD45), and neutrophil granulocytes (myeloperoxidase). Myocytolysis was visualized using complement staining (C3d). CD31 was used to identify putative thrombi. We used Mann-Whitney U testing for analysis. In the myocardium of SAH patients, the amount of myeloperoxidase-positive (P < .005), CD45-positive (P < .0005), and CD68-positive (P < .0005) cells was significantly higher compared to controls. Thrombi in intramyocardial arteries were found in 22 SAH patients and 1 control. Myocytolysis was found in 6 SAH patients but not in controls. My...Continue Reading

References

Jul 1, 1974·Progress in Cardiovascular Diseases·J I Haft
Jul 1, 1969·American Heart Journal·K E Hammermeister, D D Reichenbach
Aug 1, 1969·American Heart Journal·R C Connor
Nov 1, 1984·Stroke; a Journal of Cerebral Circulation·A Kolin, J W Norris
Oct 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Kettunen
Apr 3, 1999·Stroke; a Journal of Cerebral Circulation·S A MayerL M Klebanoff
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Takashi MasudaTohru Izumi
Jan 24, 2004·Stroke; a Journal of Cerebral Circulation·Poyee TungJonathan Zaroff
Jan 13, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alberto RoghiChiara Bucciarelli-Ducci
Dec 24, 2013·Neurology·Ivo van der BiltUNKNOWN SEASAH (Serial Echocardiography After Subarachnoid Hemorrhage) Investigators
Feb 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jacoline BoluijtMervyn D I Vergouwen

❮ Previous
Next ❯

Citations

Feb 6, 2017·Circulation Research·Pouya Tahsili-Fahadan, Romergryko G Geocadin
Nov 14, 2017·Journal of Biomaterials Applications·Hyun-Jun JangYoung-Kwon Seo
Aug 5, 2017·Circulation Research·Zhili ChenJieli Chen
Dec 6, 2019·Frontiers in Neurology·Susan MarzoliniBradley J MacIntosh
Sep 10, 2020·International Journal of Molecular Sciences·Carlo Domenico MaidaAntonio Pinto
Apr 2, 2020·International Journal of Molecular Sciences·Chengyang XuZhipeng Cao
Feb 18, 2021·Reviews in the Neurosciences·Alcivan Batista de Morais FilhoFausto Pierdoná Guzen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Mark P V BegienemanPaul A J Krijnen
Journal of the Medical Association of Georgia
B D Silverman
© 2022 Meta ULC. All rights reserved