PMID: 3383473May 1, 1988Paper

Myocarditis with multinucleated giant cells detected in biopsy specimens

Clinical Cardiology
T FukuharaS Kawakita

Abstract

A 42-year-old woman was transferred to our hospital for evaluation of bradycardia with a complete atrioventricular block. Her pulse was 41 regular beats/min with blood pressure 166/92 mmHg. There were no skin lesions, edema, or lymphadenopathy. The white blood cell count was 6300/mm3. The serum glutamic oxaloacetic transaminase was 21 IU and creatine phosphokinase was 34 IU. C-reactive protein was negative. The level of serum angiotensin converting enzyme was slightly increased at 25.8 IU/l/37.0 degrees C (normal range: 7-24.0). Chest radiography showed congestive heart failure with a cardiothoracic ratio of 54%. There was no bilateral lymphadenopathy or fibrous changes during her clinical course. The coronary arteries were completely normal angiographically. Left ventriculograms revealed slight hypokinesis and dilatation (end-diastolic volume index of 112 ml/m2, ejection fraction of 53%). Left ventricular end-diastolic pressure was slightly abnormal at 16 mmHg. Two right and two left ventricular endomyocardial biopsies were performed. Right ventricular biopsy demonstrated edematous tissue and a slight mononuclear cell infiltration with little fibrosis. Left ventricular specimens showed an extensive area of fibrosis, with large...Continue Reading

References

Jul 1, 1978·The American Journal of Cardiology·B LorellJ W Mason
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Citations

Nov 1, 1996·Cardiovascular Drugs and Therapy·M SekiguchiM Hiroe
Nov 5, 2004·Medicine·Catherine Chapelon-AbricJean-Charles Piette
Nov 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E NordborgC Nordborg
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·X FanJ Rubin
May 1, 1989·Circulation·J W Mason, J B O'Connell

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