Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

Skeletal Muscle
Courtney M AndersonBrian L Black

Abstract

Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, contractile speed, and force generation. Although skeletal muscle plays a major role in whole body metabolism, the transcription factors controlling metabolic function in muscle remain incompletely understood. Members of the myocyte enhancer factor 2 (MEF2) family of transcription factors play crucial roles in skeletal muscle development and function. MEF2C is expressed in skeletal muscle during development and postnatally and is known to play roles in sarcomeric gene expression, fiber type control, and regulation of metabolic genes. We generated mice lacking Mef2c exclusively in skeletal muscle using a conditional knockout approach and conducted a detailed phenotypic analysis. Mice lacking Mef2c in skeletal muscle on an outbred background are viable and grow to adulthood, but they are significantly smaller in overall body size compared to control mice and have significantly fewer slow fibers. When exercised in a voluntary wheel running assay, Mef2c skeletal muscle knockout mice aberrantly accumulate glycogen in their musc...Continue Reading

References

Apr 22, 1974·Pflügers Archiv : European journal of physiology·P D GollnickB Saltin
Dec 1, 1981·The Journal of Clinical Investigation·R A DeFronzoJ Wahren
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J F MartinE N Olson
May 13, 1998·Acta Physiologica Scandinavica·D Pette
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Mar 10, 2000·Journal of Applied Physiology·B RussellW W Ashley
Feb 14, 2002·Trends in Biochemical Sciences·Timothy A McKinseyEric N Olson
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael P CzubrytEric N Olson
May 27, 2004·Diabetes·Patrick Schrauwen, Matthijs K C Hesselink
Aug 6, 2004·The Proceedings of the Nutrition Society·Mark Hargreaves
Aug 26, 2004·PLoS Biology·Yong-Xu WangRonald M Evans
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shijie LiEric N Olson
Apr 14, 2005·Genesis : the Journal of Genetics and Development·Analeah B Heidt, Brian L Black
Jun 1, 2005·The International Journal of Biochemistry & Cell Biology·Aaron G Smith, George E O Muscat
Aug 18, 2005·Genesis : the Journal of Genetics and Development·Linh H VongJohn J Schwarz
Apr 20, 2006·Clinical and Experimental Pharmacology & Physiology·Sean L McGee, Mark Hargreaves
Sep 30, 2006·Annals of Medicine·Craig S StumpJames R Sowers
Jun 1, 2007·Development·Yaniv Hinits, Simon M Hughes
Aug 7, 2007·Journal of the Cardiometabolic Syndrome·Ravi Nistala, Craig S Stump
Sep 6, 2007·The Journal of Clinical Investigation·Matthew J PotthoffEric N Olson
Sep 19, 2007·Molecular and Cellular Biology·Matthew J PotthoffEric N Olson
Oct 26, 2007·Development·Matthew J Potthoff, Eric N Olson
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sean L McGee
Jul 1, 1948·Stain Technology·J F A McMANUS
Oct 21, 2011·Physiological Reviews·Stefano Schiaffino, Carlo Reggiani
Jul 1, 2003·Neuromodulation : Journal of the International Neuromodulation Society·Hazel SutherlandStanley Salmons
Jun 27, 2012·Exercise and Sport Sciences Reviews·Zhen YanNicholas P Greene
Aug 1, 2013·Physiological Reviews·Erik A Richter, Mark Hargreaves

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Citations

Nov 4, 2015·Annual Review of Physiology·Mamta Rai, Fabio Demontis
Mar 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert J ShuteDustin R Slivka
Jan 27, 2016·Development·Ralston M BarnesBrian L Black
Jul 12, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric RullmanOla Eiken
Oct 28, 2015·Oncotarget·Julia R Pon, Marco A Marra
Jan 13, 2019·The Journal of General Physiology·Niklas IvarssonHåkan Westerblad
Dec 28, 2019·International Journal of Molecular Sciences·Gideon Gatluak KangAbishek Bommannan Santhakumar
Apr 20, 2020·Acta Neuropathologica·Samir R NathAndrew P Lieberman
Oct 17, 2018·Frontiers in Cell and Developmental Biology·Isabelle Bourdeau JulienPaul A Dutchak
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Taiwo Betty AyelesoEmmanuel Mukwevho
Nov 28, 2020·Developmental Biology·Duvaraka Kula-AlwarYaniv Hinits
May 19, 2021·ELife·Quadri AdewaleUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 3, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·P HarishD Garcia de la Serrana

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Methods Mentioned

BETA
electron microscopy
transgenic

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