Aug 16, 2005

MyoD and the transcriptional control of myogenesis

Seminars in Cell & Developmental Biology
Charlotte A Berkes, Stephen J Tapscott

Abstract

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner.

  • References94
  • Citations366

Citations

Mentioned in this Paper

Vertebrates
Myoblasts
Embryo
SMARCA4 wt Allele
MYOG wt Allele
EP300 protein, human
Biochemical Pathway
MYOD1 gene
Insulin-Like Growth Factor I
Transcriptional Regulation

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