Myoepithelial carcinoma of the breast: a clinicopathological and immunohistochemical study of 15 diagnostically challenging cases.

Virchows Archiv : an International Journal of Pathology
Natalia BuzaF A Tavassoli

Abstract

Myoepithelial carcinoma (MEC) is a rare type of breast cancer composed purely of myoepithelial cells. Most often it presents with a spindle cell morphology that can mimic several benign and malignant lesions and may be misdiagnosed by the pathologist. We report 15 cases of MEC, which were sent to our consultation practice: Five of them were initially diagnosed as benign. The patients, all female, ranged from 45 to 86 years in age (mean 69.5) and-with one exception-presented with a breast mass. The tumor size measured between 1 and 4.8 cm (mean 2.6 cm). Microscopically, the tumors had infiltrative growth pattern most frequently with thin anastomosing cords of tumor cells associated with an intimately admixed reactive spindle cell stroma. The neoplastic myoepithelial cells were emanating from the myoepithelial cell layer of entrapped ductules in every case. The nuclei showed mild to moderate pleomorphism, and the mitotic activity ranged from 0 to 9/10 high power field. Immunohistochemical stains for p63, CD10, CK903, and CK5/6 reacted strongly and diffusely with the tumor cells, and mainly the reactive stroma had weak positivity for calponin, S-100, and smooth muscle actin. Estrogen receptor, progesteron receptor, and Her2 immuno...Continue Reading

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Citations

Sep 1, 2012·Surgical Pathology Clinics·Rola H Ali, Malcolm M Hayes
Dec 8, 2015·The Veterinary Journal·Raquel Sánchez-CéspedesJuana Martín de Las Mulas
Jun 2, 2015·Archives of Pathology & Laboratory Medicine·Elizabeth McKinnon, Philip Xiao
Oct 14, 2014·Archives of Pathology & Laboratory Medicine·Damoun Safarpour, Fattaneh A Tavassoli
Jan 1, 2015·Current Molecular Biology Reports·Saevar IngthorssonThorarinn Gudjonsson
May 22, 2019·Clinical Case Reports·Ryota ItoAtsushi Fukuuchi

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