Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 51 cases in a tertiary cancer center

Archives of Otolaryngology--head & Neck Surgery
Shubhada V Kane, Izhar N Bagwan

Abstract

To analyze the importance of unique cytoarchitectural patterns and the immunohistochemical profile in the diagnosis of myoepithelial carcinomas. Retrospective case analysis. Tertiary cancer center. A total of 51 patients with myoepithelial-rich carcinomas diagnosed over a 14-year period were studied for demographic data and tumor histologic characteristics and biologic behavior. We analyzed various histopathologic parameters and an immunohistochemical profile consisting of pan-cytokeratin (Pan-CK), epithelial membrane antigen (EMA), CD10, smooth-muscle actin (SMA), S-100 protein, p63, calponin, and carcinoembryonic antigen (CEA). The parotid gland (n = 15) and the palate (n = 15) were common sites involved. The cell types encountered were epithelioid, stellate, plasmacytoid, spindle, clear, and mixed with myxoid, hyaline, or myxohyaline stroma. Immunohistochemical analysis revealed vimentin (100%), CK (74%), EMA (27%), CD10 (62%), SMA (35%), S-100 protein (82%), p63 (28%), and calponin (98%) positivity and CEA (100%) negativity. Cervical node dissection was performed in 17 cases: 7 showed nodal metastasis, 2 with pure spindle-cell morphologic characteristics and 3 with spindle cells mixed with other cells. Distant metastasis wa...Continue Reading

Citations

Feb 28, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Ashumi GuptaRajiv Michael
Jun 26, 2014·Contemporary Clinical Dentistry·Jeevan LataVimal Chand
Sep 26, 2012·Case Reports in Pediatrics·Issam SalibaNabil Moukarzel
Dec 5, 2012·Acta Histochemica Et Cytochemica·Toshitaka NagaoJun Matsubayashi
Mar 29, 2012·Head & Neck Oncology·You-Hua JiangGu Zhang
Jul 7, 2011·Chest·Mastian ChandSubroto Paul
Nov 1, 2011·Journal of the California Dental Association·Carol Anne Murdoch-Kinch
Nov 8, 2011·Annals of Diagnostic Pathology·Kelly H JoggerstMichelle D Williams
Dec 30, 2015·Virchows Archiv : an International Journal of Pathology·F Passador-SantosI Leivo
Feb 4, 2012·Head & Neck·Eelam AdilDavid Goldenberg
Sep 26, 2012·Journal of Cutaneous Pathology·Hélder Antônio Rebelo PontesOslei Paes de Almeida
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Markus Winther FrostLars Bjørn Stolle
Jul 3, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S Vilar-GonzálezS Kazmi
Jun 28, 2015·Head and Neck Pathology·Gwyneth Soon, Fredrik Petersson
Apr 22, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Chenxing WangLongjiang Li
Feb 1, 2015·Annals of Surgical Oncology·Yu-Xiong SuMichael E Kupferman
Mar 13, 2014·Diagnostic Cytopathology·Abhijit ChougulePranab Dey
May 15, 2015·The American Journal of Surgical Pathology·Max KongNora Katabi
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Shaobo ZhuJennifer Hunt
Aug 15, 2014·Indian Journal of Pathology & Microbiology·Nikhil R Rabade, Naina A Goel
Aug 15, 2014·Indian Journal of Pathology & Microbiology·Yasmeen KhatibSurekha Khaire
Apr 7, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christopher C XiaoTerry A Day
Mar 1, 2018·Journal of Applied Oral Science : Revista FOB·Tibor MezeiAlina Iacob
Aug 21, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Harpreet Virk, Pranab Dey
Feb 23, 2019·The American Journal of Surgical Pathology·Bin XuNora Katabi
Apr 28, 2018·Journal of the Egyptian National Cancer Institute·Rambha PandeyAnirban Halder
Oct 26, 2012·Virchows Archiv : an International Journal of Pathology·Bharat RekhiNirmala A Jambhekar
Apr 16, 2019·Clinical Medicine Insights. Oncology·Robert G NicholasDuncan A Meiklejohn
Mar 22, 2014·Molecular and Clinical Oncology·Fen ZhaoYing Huang
Apr 29, 2016·Oncology Letters·Chenxing WangLongjiang Li
Mar 1, 2017·The British Journal of Dermatology·J-W Choi, S-Y Na
Apr 30, 2017·Oncology Letters·Karina Cecília Panelli Panelli SantosJun-Ichi Asaumi
Aug 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olca BasturkDavid S Klimstra
Feb 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maximilian LinxweilerLuc G T Morris
Feb 3, 2021·Surgical Pathology Clinics·Bin Xu, Nora Katabi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
R MinodaE Yumoto
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Daiki MasuyaHiroyasu Yokomise
Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
Leena Dennis JosephD Prathiba
© 2021 Meta ULC. All rights reserved