Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.

The American Journal of Pathology
Tanya D RussellPepper Schedin

Abstract

We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive disease. Human breast cancer MCF10DCIS.com cells were delivered into the mouse mammary teat by intraductal injection in the absence of surgical manipulations and accompanying wound-healing confounders. DCIS-like lesions developed throughout the mammary ducts with full representation of human DCIS histologic patterns. Tumor cells were incorporated into the normal mammary epithelium, developed ductal intraepithelial neoplasia and DCIS, and progressed to invasive carcinoma, suggesting the model provides a rigorous approach to study early stages of breast cancer progression. Mammary glands were evaluated for myoepithelium integrity with immunohistochemical assays. Progressive loss of the myoepithelial cell differentiation markers p63, calponin, and α-smooth muscle actin was observed in the mouse myoepithelium surrounding DCIS-involved ducts. p63 loss was an early indicator, calponin loss intermediate, and α-smooth muscle actin a later indicator of compromised myoepithelium. Loss of myoepithelial calponin was specifically assoc...Continue Reading

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Citations

Mar 19, 2016·Histopathology·Jia-Min B PangStephen B Fox
Mar 23, 2018·Endocrine-related Cancer·Berna C ÖzdemirCathrin Brisken
Jun 26, 2020·Advanced Healthcare Materials·Eric ParigorisShuichi Takayama
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May 20, 2021·IScience·Vivi DeckwirthSari Tojkander
May 18, 2021·Journal of Mammary Gland Biology and Neoplasia·Quentin JuppetDaniel Sage

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