Myoepithelial cells: any role in aspiration cytology smears of breast tumors?

CytoJournal
Sanjib Kumar PattariKusum Joshi

Abstract

To study the role of myoepithelial (ME) cells in distinguishing benign, proliferative breast diseases (PBD) and frank malignant breast lesions. In this study, histology proven 71 cases of fine needle aspiration cytology (FNAC) of palpable breast lesions were selected. There were 30 invasive carcinomas (24 infiltrating duct carcinoma and 6 infiltrating lobular carcinoma), 25 cases of benign lesion (21 fibroadenomas and 4 fibrocystic lesions) and 11 proliferative breast diseases (other than carcinoma in situ) and five cases of carcinoma in situ. The number of ME cells were estimated in respect to 1000 ductal cells. In every case at least 20 high power fields (x 40) were studied. Quantitative estimation of ME cell was correlated with the final diagnosis. Corresponding histopathology cases were also evaluated for diagnostic confirmation along with the pattern of distribution of ME cells. The ME cells were also quantitated on histopathology sections on smooth muscle actin (SMA) immunostained sections. The mean number of ME cells per 1000 ductal cells on cytology smears was 5.1 +/- 5.5, 30.8 +/- 25, 28.3 +/- 20.2, and 38.4 +/- 38.8 in malignant, carcinoma in situ, PBD and benign breast lesions respectively. The non parametric Mann Wh...Continue Reading

References

Jun 1, 1974·The Journal of Pathology·A Ahmed
Aug 9, 2001·International Journal of Surgical Pathology·Maria P. FoschiniVincenzo Eusebi
Oct 7, 2004·Diagnostic Cytopathology·Nirupma Panikar, Sarla Agarwal
Sep 21, 2005·Annals of Internal Medicine·Grazia ArpinoRichard M Elledge

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Citations

Jan 27, 2012·CytoJournal·Vinod B ShidhamMartha B Pitman
Dec 11, 2013·Clinical Medicine Insights. Pathology·Monika RathiHarshkiran Ahuja
Nov 15, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·J WeignerP McElduff

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Methods Mentioned

BETA
SMA

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