Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression

Oncology Letters
Dae Hyun SongDong Chul Kim

Abstract

Myoferlin is a protein that is associated with cellular repair following injury. The expression of myoferlin in breast cancer and pancreatic adenocarcinoma has been reported to correlate with tumor invasiveness, epithelial to mesenchymal transition and an adverse prognosis. In the present study, myoferlin expression was investigated in non-small cell lung carcinoma (NSCLC), along with its association with patient prognosis and the expression of a number of other proteins. A total of 148 patients exhibiting NSCLC were enrolled in the present study. The survival data of all patients was examined, and myoferlin, vascular endothelial growth factor receptor-2 (VEGFR-2), epidermal growth factor receptor, E-cadherin, β-catenin, thyroid transcription factor-1 and tumor protein p63 expression was investigated via immunohistochemical staining of tissue microarrays. Myoferlin expression was detected in the cytoplasm of 75/148 (50.7%) of the NSCLC cases. In the adenocarcinoma cases, myoferlin-positive patients possessed a poorer prognosis (odds ratio, 2.94; P=0.339). In the squamous cell carcinoma cases, myoferlin expression was significantly associated with VEGFR-2 expression (P=0.001). Immunohistochemical staining for VEGFR-2 and myoferl...Continue Reading

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Citations

Oct 11, 2017·Journal of Pathology and Translational Medicine·Hyo Jung AnDae Hyun Song
Nov 27, 2018·Journal of Pathology and Translational Medicine·Hyun Min KohDae Hyun Song
Jan 23, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A CoxJ Ellinger
Jul 17, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Li ZhaoXinming Zhao
Mar 21, 2018·Journal of Pathology and Translational Medicine·Min Hye KimJong Sil Lee
Aug 25, 2019·Cells·Olivier PeulenVincent Castronovo
Sep 3, 2019·Journal of Cellular and Molecular Medicine·Wei ZhuCaiping Ren
Dec 13, 2019·BioMed Research International·Yimin DongFeng Li
Oct 9, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Liqin XuJian Feng

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