Myofibroblast expression in skin wounds is enhanced by collagen III suppression

BioMed Research International
Mohammed M Al-QattanMedhat K Shier

Abstract

Generally speaking, the excessive expression of myofibroblasts is associated with excessive collagen production. One exception is seen in patients and animal models of Ehlers-Danlos syndrome type IV in which the COL3A1 gene mutation results in reduced collagen III but with concurrent increased myofibroblast expression. This paradox has not been examined with the use of external drugs/modalities to prevent hypertrophic scars. In this paper, we injected the rabbit ear wound model of hypertrophic scarring with two doses of a protein called nAG, which is known to reduce collagen expression and to suppress hypertrophic scarring in that animal model. The higher nAG dose was associated with significantly less collagen III expression and concurrent higher degree of myofibroblast expression. We concluded that collagen III content of the extracellular matrix may have a direct or an indirect effect on myofibroblast differentiation. However, further research is required to investigate the pathogenesis of this paradoxical phenomenon.

References

Sep 1, 1997·Plastic and Reconstructive Surgery·D E MorrisT A Mustoe
Feb 15, 2007·The Journal of Investigative Dermatology·Boris Hinz
Jul 21, 2007·Orphanet Journal of Rare Diseases·Dominique P Germain
Mar 13, 2009·Journal of Cutaneous Pathology·Nand L SharmaAnju Lath
Apr 1, 2010·The Journal of Hand Surgery·Andrew J WattVincent R Hentz
Jun 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elham Rahmani-NeishaboorAziz Ghahary
Jul 12, 2011·Growth Factors·Anna BiernackaNikolaos G Frangogiannis
Jan 31, 2012·Plastic and Reconstructive Surgery·Jason H KoThomas A Mustoe

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Citations

Jan 31, 2020·BioMed Research International·Yiwen ZhouXiaolu Huang

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Methods Mentioned

BETA
biopsies
biopsy
PCR

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