Myofibroblast involvement in the allergen-induced late response in mild atopic asthma

American Journal of Respiratory Cell and Molecular Biology
M J GizyckiP K Jeffery

Abstract

We undertook a detailed cellular and ultrastructural examination of bronchial biopsies from seven allergic asthmatic patients and 10 nonasthmatic control subjects (five atopic and five nonatopic) to determine the nature of the inflammation that occurs during allergen-induced late-phase responses (LPRs). The asthmatic subjects had mild asthma (FEV1 = 94 +/- 9% predicted; mean +/- SEM) and required only intermittent use of beta 2-agonists. Airway mucosal biopsy specimens were obtained on a single occasion from the nonasthmatic controls and on two occasions from the asthmatic subjects, at 24 h after diluent challenge and 24 h after challenge with allergen 3 wk later. The mean maximal decrease in FEV1 during the late response after allergen challenge was 30%, and that after administration of diluent was 4%. In coded plastic sections, subepithelial cells were counted with both light and electron microscopy, and the numbers present were expressed per 0.1 mm2 of tissue. Light microscopy revealed statistically significant increases in the total number of inflammatory cells (P < 0.02) and in "activated fibroblasts" after allergen challenge (P < 0.05). Electron microscopy showed significant increases after allergen challenge in the total...Continue Reading

Citations

Jul 28, 2001·Pediatric Pulmonology. Supplement·P Jeffery
Mar 20, 2002·Current Allergy and Asthma Reports·A M VignolaG Bonsignore
Feb 11, 2004·Current Allergy and Asthma Reports·Peter R A Johnson, Janette K Burgess
Feb 11, 2004·Current Allergy and Asthma Reports·Alastair G StewartLilly Quan
Oct 23, 2008·Current Allergy and Asthma Reports·Sana Siddiqui, James G Martin
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Jean BousquetWilliam Jacquot
Jul 4, 2012·Pulmonary Pharmacology & Therapeutics·Benjamin D Medoff
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·P ChristodoulopoulosQ Hamid
Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C MappL M Fabbri
Nov 30, 2002·Paediatric Respiratory Reviews·Lindsay Baldwin, William R Roche
Oct 1, 2003·Respiratory Physiology & Neurobiology·Andrew J Halayko, Yassine Amrani
Oct 1, 2003·Respiratory Physiology & Neurobiology·Limei Zhou, Marc B Hershenson
Jun 28, 2002·British Journal of Pharmacology·Amelia K ScaffidiDarryl A Knight
Aug 8, 2007·Immunology and Cell Biology·Simon PhippsKlaus I Matthaei
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P K Jeffery
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F M SpoelstraH F Kauffman
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·Stephen T Holgate
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·Judith L Black, Peter R A Johnson
Nov 30, 2004·Clinical and Experimental Pharmacology & Physiology·Darren J FernandesJulian Solway
Aug 8, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shigeki KuroishiKingo Chida
Sep 19, 2000·Thorax·A M VignolaG Bonsignore
Dec 26, 2006·Thorax·H BegueretJ M Tunon-de-Lara
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·P ChanezJ Bousquet
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·G MautinoF Capony
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J S ErjefältC G Persson
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·J S Erjefält, C G Persson
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·H TiddensA Bush
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·P K Jeffery
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Peter JefferyUNKNOWN Endobronchial Biopsy Workshop
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Krishnan ParameswaranPaul M O'Byrne
Jan 18, 2003·American Journal of Respiratory and Critical Care Medicine·Laurent BenayounMarina Pretolani
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Masaki TeradaNizar N Jarjour
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·Kristina Rydell TörmänenJonas S Erjefält
Sep 9, 2006·American Journal of Respiratory and Critical Care Medicine·Davinder KaurChristopher E Brightling
Jun 28, 2008·American Journal of Respiratory and Critical Care Medicine·Chun-Hua WangHan-Pin Kuo
May 2, 2009·American Journal of Respiratory and Critical Care Medicine·Tillie-Louise HackettDarryl A Knight
Apr 17, 2010·American Journal of Respiratory and Critical Care Medicine·David Ramos-BarbónJames G Martin
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Jennifer L IngramMonica Kraft
Dec 9, 1998·American Journal of Respiratory Cell and Molecular Biology·M P HallsworthS J Hirst
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·M J EvansC G Plopper
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·D I BlythS Sanjar
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·Y MorishimaK Sekizawa
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·A RichterD E Davies
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Elena A GoncharovaReynold A Panettieri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

American Journal of Respiratory Cell and Molecular Biology
C E BrewsterW R Roche
American Journal of Respiratory and Critical Care Medicine
K ParameswaranP M O'Byrne
© 2021 Meta ULC. All rights reserved